Radioactive drug targets tough lung cancers in early trial

NCT ID NCT06736418

Ongoing Disease control Sponsor: Abdera Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new radioactive drug, 225Ac-ABD147, in people with small cell lung cancer or large cell neuroendocrine lung cancer that has spread and was previously treated with platinum chemotherapy. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 17 participants will receive the drug, and some will also get an imaging agent to see where the drug goes in the body.

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Conditions

The condition(s) this trial relates to.

lung neoplasm pulmonary large cell neuroendocrine carcinoma small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LARGE CELL NEUROENDOCRINE CARCINOMA OF THE LUNG SMALL CELL LUNG CANCER ( SCLC )

Contacts and locations

Locations

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Florida Cancer Specialists - Sarasota

Sarasota, Florida, 34232, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
MD Anderson

Houston, Texas, 77030, United States
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Sylvester Comprehensive Cancer Center, Univ of Miami

Miami, Florida, 33136, United States
United Theranostics

Glen Burnie, Maryland, 21061, United States
University of California, Los Angeles

Santa Monica, California, 90404, United States
University of California, San Francisco

San Francisco, California, 94143, United States

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