Weill Medical College Of Cornell University

This study is testing a new way to personalize a non-drug treatment for depression that hasn't responded to medication. Researchers will use a special brain scan to try to match each person to the most effective type of magnetic brain stimulation. About 348 adults with treatment-…

This study is testing if time-restricted eating (eating all meals within an 8-hour window each day) can help reduce fat in the liver when added to standard diet and exercise advice. It will involve 40 adults with fatty liver disease. The main goal is to see if this eating schedul…

This study is testing whether connecting ambulances to remote pediatric emergency doctors via simple video calls can improve care for critically ill children during transport in Pakistan. About 600 children will be enrolled, with half receiving a telemedicine consultation during …

This study is testing whether taking calcium carbonate pills can help strengthen contractions during labor. It aims to see if this leads to more vaginal births and better outcomes for mothers and babies. The study is enrolling first-time mothers who are being induced or having th…

This study is testing whether a medication called propranolol can help infants born with serious heart defects grow new, healthy heart muscle cells. Researchers want to see if this treatment can improve heart growth and potentially reduce future heart problems. The study involves…

This study is testing whether liver transplantation can help patients with colorectal cancer that has spread only to their liver and cannot be removed by standard surgery. Researchers will track 20 carefully selected patients who receive a transplant to see how long they survive …

This study is testing whether adding a newer targeted drug called polatuzumab vedotin to a standard chemotherapy combination works better for people with Richter's transformation. Richter's transformation is when a slower-growing blood cancer (chronic lymphocytic leukemia) sudden…

This early-stage study is testing whether special cells from donated umbilical cords are safe and can help heal anal fistulas. The cells are engineered in a lab and injected into the fistula tract during standard surgery. Researchers will monitor 39 adult participants for side ef…

This study is testing if combining a targeted radiation treatment (stereotactic radiosurgery) with an immunotherapy drug (pembrolizumab) can better control breast cancer that has spread to the brain. It will involve about 41 adults with metastatic breast cancer who have at least …

This study is testing whether adding a special synthetic mesh during robotic anti-reflux surgery can help prevent hiatal hernias from coming back. About 200 adults scheduled for this surgery will be randomly assigned to have the procedure with or without the mesh. Researchers wil…

This study is testing if a newer surgical connection method (Kono-S) is better than the standard method at preventing Crohn's disease from returning after surgery to remove a diseased section of intestine. It will involve 600 adults with Crohn's who need their first surgery. Rese…

This study aims to find out if using two arteries instead of one during heart bypass surgery leads to better long-term results for women. It will enroll 2,300 women undergoing their first bypass surgery and randomly assign them to receive either the single or double artery techni…

This study is testing whether adding targeted radiation to standard hormone therapy drugs helps control advanced breast cancer that has spread. It will enroll 102 women with hormone-positive breast cancer that has metastasized to up to five sites. Researchers want to see if this …

This study is testing whether adding a common antifungal medication (fluconazole) to standard Crohn's disease treatments improves patient outcomes. Researchers want to see if this combination helps control symptoms better than the standard treatments alone. The trial will involve…

This study is testing if a drug called luspatercept can safely improve low blood cell counts in people with Clonal Cytopenia of Undetermined Significance (CCUS). CCUS is a condition where people have persistently low blood counts and genetic changes that put them at risk for deve…

This study is testing a laboratory technique to help eggs and sperm from couples with infertility successfully fertilize. It is for people who have had complete fertilization failure during standard IVF or one failed ICSI treatment cycle. The goal is to see if treating the eggs a…

This study is testing whether combining radiation with immunotherapy drugs can turn a patient's own breast cancer into a personalized vaccine. It involves 100 post-menopausal women with a specific type of breast cancer. The goal is to see if this combination is safe and can help …

This is an early safety study for a new gene therapy designed to treat Alpha-1 Antitrypsin Deficiency, a genetic condition that can cause serious lung disease. Researchers are testing a single injection that aims to help the body produce a protective protein long-term. The study …

This study is testing whether targeted radiation therapy can safely give breast cancer patients a second chance to keep their breast when cancer returns after previous lumpectomy and radiation. The research involves 120 patients who will receive carefully planned radiation to spe…

This study compares two types of talk therapy for people with PTSD from military sexual trauma. Researchers want to see if interpersonal therapy works as well as the more established exposure therapy. The study involves 208 participants and aims to expand effective treatment opti…

This study aims to find out which of two common procedures is better for restoring blood flow to the heart in women with blocked arteries. It compares open-heart bypass surgery to a less invasive procedure where a small mesh tube (stent) is placed. Researchers will follow 600 wom…

This study compares two common procedures for restoring blood flow to the heart in minority patients with coronary artery disease. One is minimally invasive stenting; the other is open-heart bypass surgery. Researchers will track participants for up to 10 years to see which proce…

This early-stage study is testing the safety of a new gene therapy for the serious heart muscle damage that occurs in people with Friedreich's ataxia. The therapy, called AAVrh.10hFXN, is given through an IV and aims to deliver a working copy of the frataxin gene directly to the …

This study is testing a new, highly targeted radiation treatment for men with aggressive prostate cancer. It uses advanced imaging to guide the radiation precisely to the most dangerous parts of the tumor in just five sessions. The goal is to see if this more personalized approac…

This study freezes ovarian tissue from women and girls (ages 0-45) who are at high risk of losing their fertility due to medical treatments like chemotherapy or surgery. The goal is to preserve the tissue so that in the future, the immature eggs might be matured in a lab or the t…

This study is testing a 10-week heart health program designed specifically for home health aides, who often have poor cardiovascular health. The program uses education and lifestyle support from trained 'peer coaches' who are also home health aides. Researchers want to see if par…

This early-stage study is testing the safety of an experimental vaccine designed to help people with cocaine addiction. The vaccine works by training the immune system to make antibodies that trap cocaine in the bloodstream, preventing it from reaching the brain and producing a h…

This study is for people with a dangerous, hard-to-treat heart rhythm called ventricular tachycardia. It tests if giving one dose of targeted radiation is as safe and effective as giving three smaller doses. The goal is to reduce the number of dangerous heart rhythm episodes with…

This study aims to find out if adding the blood thinner ticagrelor to standard low-dose aspirin for just one month after heart bypass surgery is better than aspirin alone. It will involve 700 patients with chronic heart disease to see which approach better prevents serious proble…

This study is testing which combination works better to shrink tumors before surgery for certain stages of non-small cell lung cancer. Before their operation, participants will receive either immunotherapy plus chemotherapy or immunotherapy plus targeted radiation. The goal is to…

This study is testing whether a minimally invasive procedure to block faulty pelvic veins can reduce chronic pelvic pain in women. Researchers will compare two groups: one receives the vein-blocking treatment, while the other receives only a diagnostic imaging procedure. The goal…

This study aims to find a safe dose for a new two-drug combination (TVB-2640 plus enzalutamide) for men with advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. It will involve about 30 participants and is the first step in testing…

This study is testing a 12-week tablet-based coaching program called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or an attempt. The program teaches skills to manage difficult emotions and aims to reduce suicide risk after people lea…

This study is testing if a specialized type of PET scan, called an FES PET/CT, can help doctors better see and plan radiation treatment for breast cancer that has spread to the brain. The scan will be given to 20 patients before their standard radiation treatment. Researchers wil…

This study is testing whether a special type of MRI scan can accurately measure and diagnose chronic pain in the jaw muscles. Researchers will compare scan results from 90 adults who have different levels of jaw pain, from none to active pain. The goal is to develop a better, mor…

This study is testing whether a special radioactive tracer can help surgeons better see and remove a type of brain tumor called a meningioma during surgery. The tracer is injected before surgery and a handheld probe is used to detect it, potentially helping the surgeon find all t…

This study is testing whether a new type of combined PET/MRI scan can help doctors better see if certain brain tumors have come back after treatment. It will involve 200 adults who have had surgery for specific brain tumors, like meningioma. The main goal is to see if this new sc…

This study is testing a new type of imaging scan called PSMA-PET CT to see if it can accurately tell when a man's low-risk prostate cancer is not dangerous. It involves 200 men who have chosen active surveillance, which means monitoring their cancer instead of immediate treatment…

This study aims to improve how chronic pain is detected and treated in people who have survived torture. Researchers will test if adding a simple pain questionnaire to a standard medical exam can dramatically improve pain detection. They will also explore what pain treatments are…

This study tests whether training religious leaders about blood pressure can help lower average blood pressure in their communities. In Tanzania, 20 communities will be involved, with half receiving the training program and half serving as a comparison group. The program teaches …

This study is testing a new middle school science curriculum designed to teach students about cancer risk and healthy choices. The program involves 14 lessons taught by regular teachers in 10 New York City public schools. Researchers want to see if learning about cancer preventio…

This study is testing whether a specially designed video game called 'No Baby No' can help teenagers use contraception more consistently. Researchers will enroll 850 teens aged 15-20 and compare the game's effects against a standard activity. The main goal is to see if playing th…

This study tests whether an online support program helps family members of people with BRCA gene mutations get tested more easily than the usual clinic-based process. It involves a patient navigator, an educational video, and a free at-home saliva test kit. The goal is to identif…

This is a small pilot study to test a new virtual therapy program that treats PTSD and chronic pain at the same time. The study will enroll 20 adults who have both conditions to see if the 12-session program is practical and acceptable to participants. The goal is to develop a mo…

This study is testing a phone-based training program for family caregivers of people with Alzheimer's or related dementias. The program teaches caregivers how to spot signs of pain in their loved ones and how to effectively communicate about it with healthcare providers. Research…

This study is testing a faster version of an FDA-approved brain stimulation treatment called TMS. The goal is to see if delivering the treatment over just 5 days can quickly reduce symptoms of depression and obsessive-compulsive disorder (OCD). Researchers will also use brain sca…

This study is looking at the best time to give a pain-numbing injection (called a TAP block) to patients having planned abdominal surgery, like weight-loss surgery. Researchers want to see if giving the injection before the first cut leads to better pain control and less need for…

This study is testing whether a safe, non-drug brain stimulation device can reduce severe fatigue in people who have had a stroke. Participants will use the device at home for 20 minutes daily over two weeks. Researchers will compare real stimulation to a placebo to see if it imp…

This study is testing whether a small, battery-powered headband that delivers a gentle, barely noticeable electrical current can help reduce chronic pain in people receiving ongoing kidney dialysis. The goal is to see if this non-drug, at-home therapy can lessen pain and potentia…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help manage anxiety and depression in adults who have had a stroke. The main goal is to see if the app is easy to use and acceptable to participants over an 8-week period. Researche…

This study is testing a new 9-week talk therapy program delivered remotely to mothers experiencing postpartum depression. The therapy focuses on reducing social isolation and increasing enjoyable social activities with loved ones. Researchers will compare this new approach to a s…

This study is testing whether watching a short, animated video about what happens during a nail biopsy can help patients feel less anxious and more informed before their procedure. Researchers will enroll 30 adults who have been recommended for a nail biopsy and randomly assign s…

This study is testing whether spiritual care services can help improve emotional and spiritual well-being for Black patients with advanced cancer. Researchers want to see if these services also help patients feel more ready to discuss their future medical care wishes. The study i…

This study is testing a therapy program called EMPOWER, designed to support family members who are making difficult medical decisions for a critically ill loved one in the ICU. The goal is to see if this program can reduce symptoms of severe grief, trauma, and regret that these f…

This study is testing an 8-week group program that teaches meditation, mindfulness, and relaxation techniques to help medical and graduate students manage their mood. The program aims to reduce symptoms of anxiety and depression through mind-body skills. Researchers will compare …

This study is testing if adding common non-opioid pain medications (like IV Tylenol and Toradol) can better control pain and reduce the need for strong opioid drugs in children who are critically ill and on a breathing machine. Researchers will enroll about 644 children aged 2 mo…

This small pilot study is testing whether virtual reality therapy can help reduce PTSD symptoms in healthcare workers and COVID-19 patients. Participants will use VR headsets during therapy sessions to safely revisit traumatic experiences. The study aims to see if this approach i…

This study is testing whether a visual stimulation device is practical and comfortable for people to use during outpatient stroke rehabilitation. It involves 25 adults who had a stroke at least six months ago. Participants will use the device for 30 minutes during their regular t…

This study is testing whether a new mobile app is easy to use and helpful for people who are pregnant or recently had a baby and are experiencing anxiety, depression, or stress. About 75 participants will use the app, which teaches therapy-based skills over 12 sessions, and provi…

This study is testing if weekly coaching sessions with a peer who also has rheumatoid arthritis (RA) can help reduce feelings of anxiety and depression. It will involve 250 adults with RA who report significant anxiety or depression. Researchers will compare the peer coaching gro…

This study is testing whether a personalized mobile therapy app is as good as a standard version at helping young adults with anxiety, depression, or bipolar disorder. About 100 participants will use one of two versions of the 'Maya' app for six weeks. Researchers will compare ho…

This study is testing a program designed to improve the mental health of home health aides, who often experience high stress and low mood. 100 aides will try an 8-week health education program, and half will also get support from a trained peer coach. Researchers want to see if t…

This study is testing an artificial intelligence (AI) tool designed to help predict the success of fertility treatments like IVF. Researchers will use the tool to analyze 3D ultrasound images of ovaries to count egg-producing follicles and see if it can accurately forecast treatm…

This study aims to collect and store breast cancer tissue and blood samples from 400 patients to create a research biobank. Researchers will use these samples to study how tumors, genes, and the immune system interact over the course of the disease. The goal is to gather knowledg…

This small pilot study aims to understand if taking an L-Phenylalanine dietary supplement changes the levels of certain fungi and a related metabolite in the gut of healthy people. Researchers will give 20 healthy volunteers the supplement for 14 days and analyze their stool and …

This study aims to collect and store tissue samples, blood, and health information from people with or at risk for colorectal or endometrial cancer. The goal is to create a resource for future scientists to study what causes these cancers and to find new targets for future drugs …

This study aims to collect leftover tissue from brain and spinal cord tumor surgeries, as well as from autopsies, to learn more about these cancers. Researchers will use the samples to grow tumor cells in the lab and test how they respond to different drugs. The goal is to find n…

This study aims to see if offering cancer gene screening during routine prenatal or fertility care is something patients are interested in and find acceptable. Researchers will offer a test for hereditary cancer risk (like BRCA genes) alongside standard prenatal genetic screening…

This study aims to understand why many COVID-19 survivors experience lasting symptoms like fatigue and shortness of breath. Researchers will use detailed heart and lung scans (MRI) on over 500 survivors to look for hidden damage. The goal is to see if these scans can help predict…

This study is collecting information on how well different focal ablation therapies work for prostate cancer. Researchers will follow 200 patients who receive treatments like focused ultrasound or freezing to destroy cancer cells. The goal is to understand treatment patterns, sid…

This study aims to collect blood, urine, and airway samples from both healthy people and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare the samples to understand what causes these diseases and how they develop. The goal is to gather basic inf…

This study is testing a special shoe called NUSHU that measures how people with Parkinson's walk. The shoe has sensors to track walking patterns and provides gentle vibrations that might help with walking difficulties. Researchers will compare 40 Parkinson's patients at different…

This study aims to collect detailed information on children and adults with genetic developmental and epileptic encephalopathies (DEEs), including a specific condition called MEF2C Haploinsufficiency Syndrome. It is not testing a treatment. Instead, researchers will track changes…

This study is testing a web-based tool called CONSYDER, designed to help young women (ages 18-44) newly diagnosed with early-stage breast cancer make informed decisions about their surgery. The goal is to see if the tool reduces confusion and anxiety, improves knowledge, and help…

This study is testing if a supplement called N-acetylcysteine (NAC) can reduce harmful stress in the brains of people with chronic fatigue syndrome (ME/CFS). Researchers will give different doses of NAC or a placebo to about 95 participants for four weeks and use brain scans and …

This study aims to understand how long numbing medicine lasts during minor skin surgeries. Researchers will test two different amounts of the same numbing medicine injected into both sides of the nose. They will check how long the numbness lasts by gently touching the area with a…