Weill Medical College Of Cornell University

This study is testing different doses of an experimental drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The main goal is to find the highest dose that can be given safely without causing severe s…

This study is testing a new two-part stem cell transplant method for adults with blood cancers who do not have a perfectly matched donor. Patients receive stem cells from both a partially matched family member and a carefully selected umbilical cord blood unit. The goal is to see…

This study is testing whether a medication called tocilizumab can help improve bone marrow transplants for people with blood cancers. Researchers want to see if using tocilizumab instead of another standard drug can help the transplant work better while reducing serious complicat…

This study is testing whether a newer, MRI-guided radiation therapy system is as effective as the current standard CT-guided system for treating early-stage breast cancer. It will enroll 17 women who have had breast-conserving surgery to see if the MRI-guided approach offers bett…

This study is testing whether a shorter radiation schedule (3 treatments) is as good as a slightly longer one (5 treatments) for women with early-stage breast cancer who have had surgery. The main goal is to see if the shorter schedule causes similar levels of skin hardening (fib…

This study compares two shorter radiation schedules for prostate cancer that has returned after prostate removal surgery. Researchers want to see if a very short 2-week schedule causes similar or fewer urinary and bowel side effects compared to a standard 4-week schedule. The tri…

This study is testing whether injecting the medication methotrexate directly into fingernails affected by psoriasis can improve symptoms like pitting, crumbling, and discoloration. Each participant will have some nails treated and others left untreated for comparison. The goal is…

This study is testing a new radioactive drug called 225Ac-J591 for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The first phase aims to find the safest dose and schedule, while the second phase checks how well it lowers …

This study is testing whether a home-delivered, whole-food, plant-based diet can help men with prostate cancer manage their weight while they are on hormone therapy. Researchers are comparing this special meal plan with standard nutritional advice in 76 overweight or obese men. T…

This study is testing a new, personalized approach for adults with untreated CLL. The goal is to see if starting with just two oral drugs is effective, and only adding a third drug (an infusion) for patients who still have detectable cancer after the first phase of treatment. Thi…

This early-stage study is testing if a medication called glycerol phenylbutyrate is safe and well-tolerated in children with rare genetic disorders that cause severe epilepsy and developmental delays. The study will enroll up to 50 children, from infants to teenagers, who have co…

This study is testing whether a special high-fat, low-carbohydrate diet (ketogenic diet) combined with the diabetes medication metformin can help control aggressive brain tumors called glioblastomas. The approach aims to lower blood sugar levels, which might slow tumor growth. Re…

This study is testing a combination of four existing drugs (daratumumab, clarithromycin, pomalidomide, and dexamethasone) for people with multiple myeloma whose cancer has returned or stopped responding to prior treatment. The goal is to see if this specific mix can better contro…

This study tested a combination of four medications for adults newly diagnosed with multiple myeloma, a blood cancer. The goal was to see if adding a newer drug called carfilzomib to an existing three-drug regimen could better control the disease and improve patient outcomes. Res…

This study is testing whether a common antibiotic, doxycycline, can slow down the worsening of emphysema in people living with HIV. About 133 participants with both HIV and emphysema will take either doxycycline or a placebo pill twice daily for 72 weeks. Researchers will measure…

This study is testing whether using a Fitbit and a mobile app can help patients recover better after major surgery for gastrointestinal cancers. About 107 patients were randomly assigned to either use the app and tracker along with their usual care, or to receive usual care alone…

This study is testing whether exchanging a person's red blood cells with healthy donor cells can help control seizures and improve brain function in people with GLUT1 deficiency syndrome. The trial will involve about 12 participants aged 16-80 who have this rare genetic disorder …

This study is testing whether a two-step treatment approach is safe and practical for men with intermediate-risk prostate cancer. First, doctors use a targeted electrical pulse treatment (IRE) to destroy the main tumor area, followed by a short course of precise, image-guided rad…

This study is testing a two-step treatment for men with aggressive prostate cancer. First, patients receive a short, intense course of targeted radiation (SBRT). Then, they undergo surgery to remove the prostate. The main goal is to find out if this combined approach is safe and …

This study is for men with advanced prostate cancer that has spread and stopped responding to standard hormone-blocking treatments. Researchers are testing if adding a new, targeted radiation drug (225Ac-J591) to a standard immunotherapy (pembrolizumab) and hormone therapy works …

This study is testing a three-part treatment for glioblastoma, a serious brain cancer. It combines a new drug called paxalisib with a high-fat, low-carb ketogenic diet and metformin, a common diabetes medication. The goal is to see if this combination is safe and can help control…

This study is testing whether adding a drug called pomalidomide to two other medications (daratumumab and dexamethasone) works better for people with AL amyloidosis that has come back or stopped responding to prior treatment. It is for patients who have already received daratumum…

This was a small, early study that planned to test a new combination treatment for liver cancer that could be removed with surgery. The goal was to see if giving a short course of targeted radiation along with two immunotherapy drugs before the operation was safe and showed signs…

This early-stage study is testing whether a very high dose of a radioactive sugar molecule (FDG), commonly used in PET scans to find cancer, can be used to treat it. The trial is for adults with advanced cancer that has spread and is no longer responding to standard treatments. R…

This study aims to find the most accurate testing method to detect early signs of cervical cancer in women living with HIV in Latin America. It involves 1002 women who will provide various samples and undergo cervical examinations to compare different screening tests. The goal is…

This study is testing whether a centralized outreach program helps more at-risk people complete lung cancer screening. Researchers will compare two approaches: one group receives letters and phone calls encouraging screening, while the other receives usual care. The goal is to fi…

This study is testing whether the 9-valent HPV vaccine can prevent persistent oral HPV infections in men living with HIV. It involves 700 adult men who will receive either the real vaccine or a placebo over several months. Researchers will track whether the vaccine reduces new, l…

This study is testing a coaching program called 'Moving Well' to see if it helps people feel less anxious and depressed before and after total knee replacement surgery. People scheduled for the surgery will work with a coach who has already had the procedure themselves. The main …

This study is testing a smartphone app designed to help older adults who have lived with HIV for many years. The app aims to reduce feelings of loneliness and depression by helping users connect with others and access helpful resources. Researchers are comparing the app to just h…

This study is checking if older adults with a rare heart condition called cardiac amyloidosis feel better and can exercise more when they stop taking their beta-blocker medicine. Twenty participants will try two periods: one on their usual dose and one with the medicine slowly re…

This study aims to see if carefully stopping beta-blocker medication helps older adults with a specific type of heart failure (HFpEF) feel better and improve their daily life. About 240 participants will be randomly assigned to either gradually stop their beta-blocker or continue…

This small pilot study is testing whether a program of educational videos and support from a health coach is helpful for people with a specific type of heart failure (HFpEF). The program aims to teach patients about their condition, medication, diet, and planning for the future. …

This study is creating a large database to learn more about Alzheimer's disease and dementia. It will follow over 450 adults, some with memory concerns and others with a family history of Alzheimer's, during their regular medical care. Researchers will collect health information …

This study aims to create a new questionnaire to measure how chronic pelvic pain affects women's lives. Researchers will interview 55 women with chronic pelvic pain to understand their experiences and develop questions that capture the full impact of their condition. The goal is …

This study aims to create and test educational materials that help people understand the difference between actual medication side effects and side effects caused by negative expectations (nocebo effect) when starting statin cholesterol drugs. Researchers will first gather experi…

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This study aims to understand the genetic reasons why Autosomal Dominant Polycystic Kidney Disease (ADPKD) varies so much in severity, even within the same family. Researchers will collect and analyze kidney tissue from 100 patients who are already scheduled to have a kidney remo…

This study is testing a personalized approach to help older adults with a common type of heart failure decide whether to continue taking their beta-blocker medication. Researchers will work with 20 participants, having each person try periods on and off their prescribed beta-bloc…

This study is testing a cancer drug called abemaciclib in bladder cancer patients who cannot receive standard chemotherapy. Twenty participants will take the drug for about a month before having their bladder surgically removed. Researchers will compare tumor samples taken before…

This is a small, early-stage study to test a new scanning method for aggressive brain tumors called high-grade gliomas. Researchers want to see if they can use two special PET scans at the same time to create a detailed map showing which parts of the tumor have low oxygen and whi…

This study aims to find out if drinking coffee or other caffeinated drinks causes changes in blood pressure or heart rate for people taking the oral medication terbinafine for nail fungus. It will enroll 52 adults who are starting the medication. Researchers will measure particip…

This study is testing whether a smartphone app called StudyU can help older adults with a specific type of heart failure (HFrEF) safely reach their recommended beta blocker dose. It's a small pilot study with just 5 participants, focusing on whether using the app for personalized…

This study aims to understand how often children experience delirium—a sudden, temporary confusion—after a stem cell transplant. Researchers are tracking over 1,000 young patients to identify what puts them at risk and how delirium affects their recovery and thinking skills. The …