University Of Sao Paulo General Hospital

This study aims to see how well a meningococcal B vaccine works in children and adolescents who have autoimmune rheumatic diseases like lupus, arthritis, or dermatomyositis. Researchers will compare the vaccine's effectiveness and safety in these patients to healthy children. The…

This study is testing whether a single-dose dengue vaccine is safe and works well for people with autoimmune diseases like rheumatoid arthritis or lupus. Researchers will compare about 320 patients with these conditions to 160 healthy volunteers, all living in areas where dengue …

This study aims to see how well patients with a serious type of high blood pressure in the lungs, caused by chronic lung diseases, fare over time when treated with an inhaled medication called iloprost. It will look back at the medical records of about 50 adults who have already …

This study aims to roll out and test a smartphone app called CONEMO to help adults manage symptoms of depression, anxiety, and insomnia. It will involve over 12,000 people who use primary healthcare services in two Brazilian cities. The goal is to see how well this proven digital…

This study is testing whether an inhaled medication called iloprost is safe and effective for treating high blood pressure in the lungs of adults with severe COPD. Researchers want to see if the drug lowers pressure in the lung's blood vessels and helps people walk farther. Fifte…

This study aims to see if a newer, less-studied video scope (BESDATA BD-DF) works as well as a more common one (McGRATH MAC) for safely placing a breathing tube in infants and young children during surgery. Researchers will compare how often each device succeeds on the first try,…

This study aims to help women who had diabetes during pregnancy (gestational diabetes) get an important follow-up blood sugar test after giving birth. Researchers will test if sending reminder messages via WhatsApp increases the number of women who attend their scheduled test. Th…

This study is testing whether taking a daily antiviral pill (acyclovir) can prevent painful and frequent herpes outbreaks in people with autoimmune diseases like lupus or rheumatoid arthritis. These patients often take medications that weaken their immune system, making them more…

This study aims to find the best way to teach young students about preventing burns and providing first aid. Researchers will compare learning from a special educational video game to learning from a traditional in-person lecture. They will measure how much knowledge students gai…

This study aims to find out if a single dose of an antibiotic is needed to prevent infection after a simple tooth extraction in people with autoimmune diseases (like rheumatoid arthritis or lupus) who take medications that weaken their immune system. Participants will be randomly…

This study looks at whether switching adults with pulmonary arterial hypertension (PAH) from an inhaled medication that requires multiple daily uses to a twice-daily oral pill improves their quality of life and makes it easier to stick with treatment. Researchers will follow 32 p…

This study is testing whether a gentle, non-invasive form of focused ultrasound can reduce shaking (tremor) in people with essential tremor. Twenty adults whose tremor is not well-controlled by medication will receive both a real and a fake (sham) ultrasound treatment in a random…

This study aims to understand how newborns with esophageal atresia fare in Brazil by collecting data from 72 hospitals. Researchers will track 1000 babies to see what treatments work best and what factors lead to complications. The goal is to create better national care guideline…

This study aims to find out if temporarily stopping the common autoimmune drug methotrexate for two weeks after getting a pneumonia vaccine helps the body build a stronger immune response. It will involve 192 adults with stable autoimmune diseases. Researchers will compare the va…

This study aims to learn where patients with pulmonary hypertension and their caregivers look for health information and what topics they search for most. Researchers will survey 100 patients and 100 caregivers using a short questionnaire about their information sources, satisfac…

This study aims to better understand and diagnose people who experience brief episodes of vertigo or dizziness that last less than a day. Researchers will observe 400 patients over time to see how their diagnosis might change, what treatments they receive, and what their health o…