Stephanie B. Seminara, Md

This early study tested whether a naturally occurring hormone called kisspeptin can stimulate reproductive hormones and help women with hypothalamic amenorrhea (a condition where periods stop due to low hormone levels) release eggs. Thirteen women received pulsatile injections of…

This study tested a new treatment using kisspeptin for people with hypogonadotropic hypogonadism, a condition where the body doesn't make enough sex hormones. 18 adults received the treatment to see if it could safely boost hormone levels. The goal was to find a better way to man…

This completed Phase 1 study looked at how naloxone, an opioid blocker, affects reproductive hormones in 47 healthy adults. Participants had genetic data available from the Mass General Brigham Biobank. Researchers measured changes in luteinizing hormone pulses before and during …

This small study gave 8 women with PCOS a continuous infusion of kisspeptin, a hormone that controls reproduction. Researchers measured changes in luteinizing hormone pulses to see how the reproductive axis responds. The goal was to learn more about the hormone system in PCOS, no…

This study looked at how a drug that blocks opioids (naloxone) affects hormone signals in the brain related to testosterone. 23 men with a condition called hypogonadotropic hypogonadism (low testosterone) took part. The goal was to understand the body's hormone control, not to tr…

This study looked at how people understand risk from genetic testing. Over 1,000 participants were shown different visual aids and asked to estimate their risk. The goal was to find which visual aid helps people most accurately understand genetic risk and how they feel about shar…