Could a natural hormone restore ovulation in women with hypothalamic amenorrhea?
NCT ID NCT05633966
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 34 times
Summary
This early study tested whether a naturally occurring hormone called kisspeptin can stimulate reproductive hormones and help women with hypothalamic amenorrhea (a condition where periods stop due to low hormone levels) release eggs. Thirteen women received pulsatile injections of kisspeptin under the skin for two weeks. Researchers monitored egg development with ultrasound and measured hormone levels through frequent blood draws to see if the treatment could trigger ovulation.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
kisspeptin (a naturally occurring hormone)
What this could lead to
If it works, this could point toward a new treatment for women with hypothalamic amenorrhea to help them ovulate without traditional hormone therapies.
What could go wrong
This is a very small, early Phase 1 trial with only 13 participants. It is designed to test safety and basic effects, not to prove effectiveness. The results may not apply to all women with reproductive disorders.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.