Opioid blocker trial probes hormone secrets in biobank volunteers
NCT ID NCT04975347
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 36 times
Summary
This completed Phase 1 study looked at how naloxone, an opioid blocker, affects reproductive hormones in 47 healthy adults. Participants had genetic data available from the Mass General Brigham Biobank. Researchers measured changes in luteinizing hormone pulses before and during naloxone infusion to understand the brain's control of reproduction.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Naloxone
What this could lead to
If successful, this could help explain how opioid blockers influence reproductive hormone regulation in people with certain genetic variants.
What could go wrong
This is a small, early-phase study in healthy volunteers, so results may not apply to people with reproductive disorders or lead to a treatment.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.