Stephan Grupp Md Phd

This early-stage study is testing the safety and effectiveness of a new cell therapy called BEAM-201 for children and young adults whose T-cell leukemia or lymphoma has come back or hasn't responded to standard treatments. BEAM-201 uses immune cells from a healthy donor, engineer…

This is the first time researchers are testing a new type of cell therapy called GPC2 CAR T in children. The trial aims to find a safe dose for kids with advanced neuroblastoma or metastatic retinoblastoma that has come back or hasn't responded to all other standard treatments. D…

This is the first-ever study in people to test a new type of CAR-T cell therapy called PHOX2B PC-CAR T for children with advanced, high-risk neuroblastoma that has come back or not responded to other treatments. The main goal is to find a safe dose and see if the treatment can be…

This study is testing a stem cell transplant procedure for children and young adults with severe, life-threatening forms of lupus or scleroderma that haven't responded to standard treatments. The goal is to use high-dose chemotherapy to wipe out the faulty immune system and then …

This study is testing a new, faster way to make a personalized cancer treatment called CAR-T cell therapy for children and young adults with a hard-to-treat blood cancer called B-cell acute lymphoblastic leukemia (B-ALL). The goal is to see if using an automated machine to make t…

This study is testing a new, two-part version of CAR-T cell therapy for children and young adults whose B-cell leukemia has come back or not responded to other treatments. It combines two specially engineered immune cell therapies to try to prevent the cancer from returning. The …

This study is testing a personalized cell therapy called CART19 for children and young adults with specific, very high-risk types of B-cell acute lymphoblastic leukemia (B-ALL) that are difficult to treat with standard methods. It aims to see if using the patient's own modified i…