Semmelweis University

This study tests whether adding a non-invasive heat therapy called modulated electro-hyperthermia (mEHT) to standard chemotherapy can shrink tumors more effectively in women with HER2-negative breast cancer. About 71 participants with stage II-III disease will receive chemo with …

This study tests whether using a patient's own extracted tooth as a bone graft works as well as a traditional bone graft to repair bone damage from severe gum disease. Sixty adults with chronic periodontitis will receive one of the two graft types, both combined with a healing ge…

This study compares two types of dental onlays (custom-made tooth covers) for treating decayed teeth. 164 adults will each receive one milled and one 3D-printed onlay to see which lasts longer over 10 years. The goal is to find out if the newer 3D-printing method is as good as th…

This study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…

This study tests whether a custom 3D-printed surgical guide helps dentists expose impacted canine teeth more quickly and accurately than the traditional free-hand method. Forty teenagers aged 11-18 with one or both upper canine teeth stuck in the palate will be randomly assigned …

This study tests a type of brain stimulation called theta-burst rTMS in 54 adults with depression that hasn't responded to other treatments. The goal is to see if it eases depression and thinking problems, and to use brain scans to predict who will benefit. Participants receive d…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

This study looks at how a person's genetic makeup and brain activity influence their sensitivity to both positive and negative life events. Researchers will use genetic data from over 500,000 people and brain scans to identify who might benefit most from stress management therapy…