Regeneron Pharmaceuticals

This study tests an experimental drug, alirocumab, given once a week to adults with high cholesterol. The goal is to see how well it lowers LDL (bad) cholesterol and what side effects may occur. About 420 participants will take part to find the best dose and check safety.

This study tests two experimental drugs, fianlimab and cemiplimab, in children and young adults whose high-grade glioma or ependymoma has returned or worsened. The goal is to see if the drugs are safe and can shrink tumors or slow their growth. Participants will receive the drugs…

This early-stage study tests BPX-601, a personalized CAR-T cell therapy made from a patient's own immune cells, for advanced prostate cancer that has stopped responding to standard treatments. The main goals are to find the safest dose and understand side effects. Up to 36 partic…

This study tests if a new drug, linvoseltamab, can delay the development of active multiple myeloma better than an existing drug, daratumumab, in people with smoldering multiple myeloma who are at high risk. About 270 participants will be randomly assigned to one of the two treat…

This study tests a new drug, linvoseltamab, added to standard chemotherapy for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. Researchers want to see if the new combination works better than the current standard treatment, and whether it…

This study tests whether adding the drug dupilumab to standard COPD treatment can prevent another serious flare-up after a hospital stay. About 754 adults with COPD who have high levels of certain white blood cells will receive either dupilumab or a placebo for around 90 days. Th…

This study tests an experimental drug, ALN-PNP, alone or with a weight-loss drug (like tirzepatide), in 204 adults with a genetic form of fatty liver disease (MASLD). The goal is to see if lowering a specific protein (PNPLA3) can reduce liver fat. Participants must have a specifi…

This study tests an experimental drug called garetosmab in children and teens with fibrodysplasia ossificans progressiva (FOP), a rare genetic condition where soft tissues turn into bone. The goal is to see if the drug is safe and can reduce new abnormal bone growth and flare-ups…

This study tests two experimental drugs, REGN7508 and REGN9933, to see if they can prevent life-threatening blood clots in people with peripheral artery disease (PAD) who recently had leg surgery to improve blood flow. About 7,050 adults will be randomly assigned to receive one o…

This study tests an experimental drug, REGN7508, to see if it works better than the standard blood thinner apixaban for treating and preventing blood clots in people with cancer. About 1,600 participants with or without cancer will be enrolled. The goal is to check how safe and e…

This large, late-stage study is testing two new injectable drugs, REGN7508 and REGN9933, to prevent strokes and blood clots in people with an irregular heartbeat called atrial fibrillation. The study is specifically for people who cannot or choose not to take standard oral blood …

This early-stage study tests a new drug called REGN20934 in 90 adults with overweight or obesity. The main goal is to check if the drug is safe and what side effects it may cause. Researchers will also measure how the drug moves through the body and whether the immune system reac…

This early-stage study tests a new medicine called REGN20423 for the first time in humans. It will check the drug's safety, how the body handles it, and what dose might work best. The study includes 136 people: healthy volunteers and adults with atopic dermatitis (eczema). Resear…

This early-stage study tests a new drug called REGN22044 in 64 healthy adults for the first time. Researchers will check for side effects, measure drug levels in the blood, and see if the body makes antibodies against it. The goal is to gather safety information, not to treat any…