Otsuka Pharmaceutical Development & Commercialization, Inc.

This study tests the safety of a drug called tolvaptan in children aged 28 days to 18 years who have a rare inherited kidney disease called ARPKD. The goal is to see if the drug can slow kidney function decline and reduce the need for dialysis or a kidney transplant. About 20 chi…

This study tests if a new drug, quabodepistat, combined with other TB medicines, can treat drug-resistant tuberculosis (TB) in just 4 months instead of the usual 6 months. About 532 adults and teens with rifampicin-resistant or multidrug-resistant TB will be randomly assigned to …

This study tests the long-term safety of an experimental drug called JNT-517 for children and adults with phenylketonuria (PKU), a genetic condition that causes harmful buildup of phenylalanine. About 240 participants who completed earlier JNT-517 studies or are new to the drug w…

This study tests an oral medication called JNT-517 for adults with phenylketonuria (PKU), a genetic condition that makes it hard to break down an amino acid called phenylalanine. About 120 adults will take either JNT-517 or a placebo for 6 weeks, then everyone gets JNT-517 for al…

This early-stage trial tests a new drug called VIS171 in 30 people with autoimmune diseases like lupus, alopecia areata, or a kidney condition. The main goal is to check if the drug is safe and tolerable when given as a shot under the skin. Participants will be followed for up to…

This study tests a new medication called Ulotaront (SEP-363856) to see if it can safely reduce severe symptoms like hallucinations and delusions in people with schizophrenia. About 522 adults experiencing an acute psychotic episode will receive either the drug or a placebo for 6 …

This early-phase study tests how well the experimental drug MSP-2020 attaches to serotonin receptors in the brains of 18 healthy men. Researchers will use PET scans to measure receptor occupancy and track the drug's levels in the blood. The goal is to gather safety and dosing inf…

This study tests how a new drug called repinatrabit interacts with several common medications, including birth control pills, metformin, carbamazepine, rosuvastatin, and methotrexate. It involves 48 healthy volunteers and aims to measure drug levels in the blood. The results will…