National Jewish Health

This study looked at 51 adults with cystic fibrosis to compare two IV antibiotics (tobramycin and colistin) used for lung infections. The goal was to see if a new, less frequent dosing schedule for colistin could reduce kidney damage while still fighting the infection effectively…

This study tested whether sildenafil, a drug often used for other conditions, can reduce inflammation in the lungs of people with cystic fibrosis (CF). Researchers measured changes in sputum and breath markers in 36 participants aged 12 and older with stable lung function. The go…

This pilot study tested whether inhaling a drug called rh-DNase for 4 weeks helps adults with neutrophilic asthma, a type of asthma with high inflammation. Nineteen participants took part to see if the treatment improved lung function and symptom control. The goal was to find a n…

This study looked at 29 adults with cystic fibrosis who were hospitalized for a lung infection. Researchers collected blood, sputum, and urine samples to study how infection and inflammation affect recovery of lung function. The goal is to find better ways to personalize treatmen…

This study followed 58 adults with cystic fibrosis to see how their bodies respond to CFTR modulator treatments. Researchers collected blood, sputum, urine, and quality-of-life surveys before and after starting the drugs. The goal was to track changes in inflammation, lung bacter…

This study looked at how strong and long-lasting the immune response to COVID-19 vaccines is in 360 adults and children with chronic medical conditions like lung disease. Researchers measured antibodies and immune cells before vaccination and every 3 months for 18 months after. T…

This study looked at sputum (mucus coughed up from the lungs) from 83 adults with cystic fibrosis who were hospitalized for a sudden worsening of their lung disease. Researchers used genetic testing to find which antibiotic-resistant bacteria were present and compared those resul…