National Institute On Drug Abuse (nida)

This early-stage study is testing if spironolactone, a drug approved for high blood pressure, is safe for people with alcohol use disorder and how it interacts with alcohol. Researchers will give 20 participants different doses of the drug during four week-long clinic stays, wher…

This study is testing whether different activities and environments can help people with alcohol use disorder drink less and feel better. Participants will try activities like virtual reality, games, and crafts during some visits, and watch videos during others, to see what effec…

This study is testing whether a combination of two existing medications can help people reduce or stop using methamphetamine. 360 adults with moderate to severe methamphetamine addiction will receive either the active drug combination or placebo injections and pills for 12 weeks.…

This study is testing if semaglutide, a medication currently used for weight loss and diabetes, can help people with alcohol use disorder drink less. About 52 adults will receive weekly injections of either the real medication or a placebo (dummy shot) for 20 weeks. Researchers w…

This study is not a treatment trial. Its main purpose is to screen and evaluate people to see if they qualify for other future research studies on addiction. Researchers want to understand why some people use drugs, why some get addicted, and why others don't. They will collect h…

This study aims to build a large research database to understand why people relapse after starting treatment for alcohol or drug use. Researchers will collect data from 10,000 adults in the U.S. who have used substances recently. Participants will use a smartphone app that runs i…

This study uses brain scans to understand how nicotine affects brain function in people with and without major depression. Researchers will give participants either nicotine or a placebo before MRI scans to see how their brains respond during tasks. The goal is to learn why peopl…

This study aims to create and test new, advanced brain scanning techniques to see how drug addiction changes the brain. Researchers will scan the brains of up to 1,000 adults, including both people who use drugs and those who don't, to compare the differences. The goal is to deve…

This study aims to understand if there are differences in how people with opioid addiction learn and make decisions compared to those without addiction. Participants will complete a computer task that pairs shapes with food smells to test basic brain functions. The goal is to gat…

This study aims to understand how a non-invasive brain stimulation technique called TMS affects brain activity in healthy people. Researchers will use MRI scans to watch brain changes while applying magnetic pulses to the forehead area. The knowledge gained could help design bett…

This study aims to understand how a prescription sleep medication called suvorexant affects the brain activity related to smoking addiction. Researchers will give the drug to daily smokers and use brain scans to see if it reduces cravings triggered by smoking cues and changes how…

This study aims to understand how a non-invasive brain stimulation technique affects learning and decision-making in healthy people. Researchers will use a magnetic coil on the head and brain scans while participants do computer tasks. The goal is to gather basic knowledge that c…

This study aims to create and test a set of computer-based tasks to measure how people learn and make decisions. Researchers want to understand if these tasks can reliably measure thinking patterns, which may help explain why some people develop substance use disorders. Healthy v…