National Institute Of Mental Health (nimh)

This study tested a new approach for treating major depression that combines two treatments. Researchers used MRI scans to precisely target a brain stimulation treatment (rTMS) while participants also did a computer-based talk therapy session. The goal was to see if doing both tr…

This study aimed to test a short questionnaire designed to identify suicide risk in children and teenagers with autism or similar conditions. Researchers worked with 278 youth and their parents to see if the questions accurately detected thoughts of self-harm. The goal is to crea…

This study tested if a new experimental drug could prevent mood symptoms from coming back when women with a history of perimenopausal depression stopped taking estrogen. Researchers gave 74 healthy, postmenopausal women estrogen patches for three weeks, then randomly gave them ei…

This study aimed to understand how cooling the brain and the timing of brain stimulation affect brain activity. Healthy volunteers wore a cooling cap and received non-invasive magnetic brain stimulation while their brain waves and muscle responses were measured. The goal was to g…

This study aimed to better understand brain disorders like schizophrenia by comparing detailed brain scans of patients with scans from healthy volunteers. Researchers used advanced MRI and MEG imaging technology to look for differences in brain structure, chemistry, and activity.…

This completed study aimed to better understand how the brain works in people with autism spectrum disorders (ASD). Researchers studied 678 participants, including people with ASD, healthy volunteers, and their parents, using interviews, thinking tests, brain scans (MRI/MEG), and…

This completed observational study aimed to understand why some women experience mood changes during the transition to menopause. Researchers followed 1,158 women aged 40-65, comparing those with depression symptoms to healthy volunteers, to examine how hormone changes might affe…

This study aimed to understand if sudden hormone changes after childbirth cause postpartum depression. Researchers gave hormones to 74 women with and without a history of depression to mimic pregnancy, then stopped them suddenly to see if mood symptoms appeared. The goal was to l…

This study used brain imaging (PET scans) to learn how the frontal lobe works during thinking tasks. It compared healthy volunteers to people with conditions like schizophrenia and Parkinson's disease. The goal was to understand how brain activity relates to thinking problems in …

This large, completed study aimed to understand the genetic and brain function factors behind schizophrenia and related disorders. Researchers compared patients, their siblings, and healthy volunteers to identify genes that might increase risk and affect thinking skills. The goal…

This study aimed to understand how mood disorders, anxiety, and migraines run in families. Researchers interviewed nearly 2,000 participants, including children and adults, to identify patterns and risk factors across generations. The goal was to gather knowledge to help improve …

This study used brain scans (fMRI) to understand how a person's basic temperament might be connected to their brain's activity. Researchers looked at children and adults to see if certain patterns of brain response during emotional tasks could help explain why some people are mor…

This study used special brain scans (PET scans) to measure dopamine activity and blood flow in the brains of healthy volunteers, people with Parkinson's disease, and people with schizophrenia. Researchers compared these measurements across groups to better understand how dopamine…

This study aimed to understand the biological basis of schizophrenia by seeing how the illness itself affects the brain, separate from the effects of medication. Researchers temporarily stopped antipsychotic drugs for 648 participants with schizophrenia in a closely monitored hos…

This study aimed to improve non-invasive brain stimulation (NIBS) techniques, which have potential for treating brain disorders. Researchers worked with 83 healthy volunteers to test different stimulation settings and measure brain responses using MRI, EEG, and simple tasks. The …

This study aimed to better understand how brain chemistry differs in people with schizophrenia. Researchers used special brain scans (PET and MRI) to measure dopamine receptors in 283 participants, including healthy volunteers and people with schizophrenia. The goal was to gather…