Merck Healthcare Kgaa, Darmstadt, Germany, An Affiliate Of Merck Kgaa, Darmstadt, Germany

This study looked at how well the drug avelumab works as a maintenance treatment for people with advanced bladder cancer that hasn't gotten worse after initial chemotherapy. The study included 106 adults and followed them for about 4 years to track safety and how long they lived.…

This study looked at how well avelumab (BAVENCIO) plus axitinib (INLYTA) works as the first treatment for people with advanced kidney cancer. Researchers followed 105 patients in Europe to see how many were alive after 12 months and how the treatment affected their cancer. The go…

This study tested whether a single dose of two drugs (M5717 and pyronaridine) can clear hidden malaria parasites and protect against new infections for weeks. It involved 192 adults and teens who had malaria but no symptoms. The goal is to find a simple, one-time preventive treat…

This study looked at how a drug called evobrutinib affects the way the body handles four other common medicines: digoxin, metformin, rosuvastatin, and sumatriptan. Forty healthy adults took part to help researchers understand these interactions. The goal was to gather safety and …

This study looked at how the body absorbs and processes a single dose of Pergoveris, a fertility drug containing two hormones (FSH and LH), in 24 healthy women of Japanese or Caucasian origin. Participants took a birth control pill for about 4 weeks to suppress their natural horm…

This study looked at how the drug carbamazepine changes the way another drug, evobrutinib, moves through the body. Fourteen healthy adults took both drugs in a specific order, and researchers measured drug levels in their blood. The goal was to understand the interaction, not to …

This study looked at how different manufacturing batches of the drug evobrutinib are absorbed by the body in 28 healthy adults. The main goal was to compare drug levels and safety between batches. Participants took a single dose under fasting conditions, and researchers measured …

This study looked at how the drug tuvusertib is absorbed, broken down, and removed from the body in 12 people with advanced solid tumors. Participants received a special radioactive tracer to track the drug. The main goal was to understand the drug's path in the body, not to trea…

This study looked at whether a wearable sensor could help monitor Chronic Obstructive Pulmonary Disease (COPD) and predict sudden worsening of symptoms, known as exacerbations. 77 people with COPD wore a device for 3 months that tracked things like heart rate, activity, and cough…

This study looked at how evobrutinib, an experimental drug, changes the way a common birth control pill works in 20 healthy women. Participants took both medications and had their blood levels measured. The goal was to see if evobrutinib affects birth control hormone levels, whic…

This study looked at how the drug evobrutinib is processed in people with different levels of liver impairment compared to those with healthy livers. Twenty-four participants received a single dose, and researchers measured drug levels in the blood and monitored safety. The goal …

This study checked whether a single dose of evobrutinib, an experimental drug, changes the heart's electrical activity (QT interval) in 36 healthy adults. Participants received evobrutinib, a placebo, or another drug for comparison. The goal was to see if evobrutinib could cause …

This study looked at how different levels of kidney function affect the way the body handles a drug called enpatoran. 34 adults with normal or impaired kidneys received a single dose. Researchers measured drug levels in the blood and checked for side effects. The goal was to unde…