Melanoma Institute Australia

This study tests whether giving two targeted drugs (dabrafenib and trametinib) for 12 weeks before surgery can shrink melanoma that has spread to lymph nodes. It involves 35 adults with stage IIIB-C BRAF V600 mutation-positive melanoma. The main goal is to see how much cancer tis…

This study tests whether giving two immunotherapy drugs (relatlimab and nivolumab) before surgery can shrink or eliminate tumors in people with high-risk stage II melanoma. About 20 participants will receive two doses of the drugs, then have surgery to remove any remaining cancer…

This study tests whether the immunotherapy drugs nivolumab and ipilimumab, alone or together, can shrink melanoma tumors that have spread to the brain. It involves 76 adults with stage IV melanoma and at least one brain metastasis. The main goal is to see how many patients have t…

This study tests whether giving two drugs, pembrolizumab and lenvatinib, before surgery can help shrink tumors in people with stage III melanoma that can be removed. About 21 adults with resectable stage III melanoma will receive the drugs for 6 weeks, then have surgery to remove…