Institute Of Tropical Medicine, Belgium

This large phase 3 study tests whether a new two-dose combination of bedaquiline and rifampicin can better prevent leprosy than the current standard single-dose rifampicin. About 124,000 people living within 100 meters of a leprosy patient in the Comoros will receive either the n…

This study looks at how well the mpox vaccines MVA-BN and LC16m8 work by measuring immune responses in 300 vaccinated adults in the Democratic Republic of the Congo. Participants give blood samples over several months to see how long protection lasts. The goal is to better unders…

This study follows 345 people who had mpox or received the smallpox vaccine to see if they have any lasting physical or mental health issues and how long their immune protection lasts. Participants will give blood, saliva, semen, and anal swabs at checkups over 5 years. The goal …

This study looks at how doctors in the Democratic Republic of Congo treat fevers and whether new tools—like a simple blood test (CRP), a WHO antibiotic guide, and electronic decision aids—can help them use antibiotics more wisely. Researchers will follow 500 adults and children w…

This study follows 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to understand why the parasite persists and causes repeat infections. They will analyze host and pathogen factors to improve treatment monitoring.…