Institute Of Liver And Biliary Sciences, India

This study compares a higher volume of plasma exchange to the standard amount in 60 adults with sudden liver failure and brain swelling. The goal is to see if the higher dose helps the brain recover faster and improves survival without needing a liver transplant. The treatment ai…

This study tests a blood filtering treatment called DPMAS for people with acute-on-chronic liver failure, a sudden worsening of chronic liver disease that can be life-threatening. About 56 adults will be randomly assigned to receive either standard care alone or standard care plu…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study tests whether starting the drug midodrine early can help control ascites (fluid buildup in the belly) and prevent kidney complications in people with acute-on-chronic liver failure. About 113 adults with moderate to severe ascites will receive either midodrine plus sta…

This study tests whether adding midodrine to the standard drug carvedilol can prevent early rebleeding in people with liver cirrhosis who have had a variceal bleed. About 210 adults with moderate to severe cirrhosis will be randomly assigned to receive either both drugs or carved…

This study tests whether adding vitamin C to standard treatment can help patients with severe liver disease (ACLF) who have a serious infection (septic shock) and kidney injury. Vitamin C is a safe, cheap antioxidant that may reduce inflammation and protect the kidneys. The study…

This study tests whether the drug finerenone can prevent chronic kidney disease in 160 adults with fatty liver disease (MASLD), cirrhosis, and fluid in the belly (ascites). Participants will receive either finerenone or spironolactone alongside standard care. The main goal is to …

This study follows 100 adults with chronic liver disease who are hospitalized for sudden liver or other organ failure. Researchers will track their health for 6 months to see who recovers, needs a transplant, or dies. The goal is to better understand how the disease progresses an…

This study checks how many adults with cirrhosis are immune to hepatitis A and how well a single vaccine dose works for those who aren't. About 360 participants will give blood samples and some will receive the vaccine. Results will help doctors decide who needs the shot.