Hamilton Health Sciences Corporation

This study tests whether a catheter-based procedure to close a small pouch in the heart (the left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are still at high risk despite taking blood thinners. About 4,000 participants will be ran…

This study tests if giving two medicines—tranexamic acid and desmopressin—before surgery can reduce bleeding in people with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see if these…

This study tests an experimental drug called tideglusib in 120 people with a genetic form of heart muscle disease that raises the risk of dangerous heartbeats. Participants must have a specific gene change and at least 500 extra heartbeats per day. The goal is to see if the drug …

This study looks at whether using a dye called indocyanine green (ICG) alone is as accurate as the usual two-method approach (ICG plus a radioactive tracer) for finding cancer that has spread to lymph nodes in early vulvar cancer. About 58 women with early-stage vulvar cancer wil…

This study tests whether a numbing injection (bupivacaine) into a nerve cluster in the face can reduce pain after minimally invasive pituitary tumor surgery. About 108 adults will receive either the nerve block, a placebo, or no extra injection during surgery. Researchers will tr…

This study compares two common methods for anterior cervical spine surgery: the Smith-Robinson approach and the strap-splitting approach. Both use the same skin cut but differ in how the surgeon reaches the spine. The goal is to see which approach leads to fewer swallowing and vo…