Gruppo Italiano Malattie Ematologiche Dell'adulto

This study tests whether adding the drug daratumumab to standard chemotherapy can completely clear leukemia cells in adults aged 18-65 with very high-risk T-cell acute lymphoblastic leukemia (T-ALL). The main goal is to see if more patients have no detectable cancer after the fir…

This study tests a drug called ponatinib combined with chemotherapy as a first treatment for adults aged 18-65 with a high-risk type of acute lymphoblastic leukemia (BCR/ABL1-like ALL). The goal is to see if this targeted approach can make the cancer undetectable in the bone marr…

This study tests a two-step treatment plan for young adults (up to age 65) with high-risk chronic lymphocytic leukemia (CLL) who have not had prior therapy. First, patients receive a combination of venetoclax and obinutuzumab. Then, based on whether any cancer cells remain, they …

This study is gathering information from 572 people in Italy with Philadelphia-negative myeloproliferative neoplasms (MPN), a group of rare blood cancers. Researchers are using surveys to measure how the disease and its treatments affect patients' well-being, symptoms, and daily …

This study looks at how a protein called adrenomedullin helps leukemia cells grow and spread in the bone marrow. Researchers will collect blood and bone marrow samples from 72 adults newly diagnosed with acute myeloid leukemia (AML). They will measure protein levels and run lab t…