First Affiliated Hospital Xi'an Jiaotong University

This early trial tests a gene therapy called NGGT006 in people with homozygous familial hypercholesterolemia, a rare inherited condition causing extremely high LDL cholesterol and early heart disease. The therapy uses a harmless virus to deliver a working copy of the LDL receptor…

This phase 3 trial tests whether giving a clot-busting drug called rhPro-UK before a mechanical clot removal procedure improves recovery for people with severe stroke. About 820 participants who had a stroke 4.5 to 24 hours earlier will receive either the drug or a placebo, follo…

This trial tests whether giving a combination of adebrelimab, famitinib, and chemotherapy before surgery can eliminate cancer cells in people with esophageal squamous cell carcinoma. The study enrolls 24 adults with resectable, locally advanced tumors. Participants receive two cy…

This study tests whether giving a Chinese herbal medicine called Realgar-Indigo naturalis formula (RIF) together with standard vitamin A therapy right away can lower the risk of early death in people with a fast-growing blood cancer called acute promyelocytic leukemia (APL). Abou…

This study tests whether ursodeoxycholic acid (UDCA), a drug used for bile duct problems, can stop statins from raising blood sugar. 128 adults with high cholesterol but normal blood sugar will take either UDCA or a placebo alongside atorvastatin for 6 months. Researchers will tr…

This study compares a new drug called leymovir to the standard drug valganciclovir for preventing cytomegalovirus (CMV) infection in 290 Chinese kidney transplant recipients. Leymovir targets a different part of the virus, which may reduce side effects like bone marrow suppressio…

This study tests whether closing a small hole in the heart (called a PFO) can reduce migraine attacks and improve brain function. Researchers will compare 150 adults with migraines and a PFO who get the closure procedure to those who don't. The goal is to see if the procedure cut…

This study looks at whether certain fat molecules in the blood, called lipids and ceramides, are linked to atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from people with atrial fibrillation to those with other heart conditions but no a…

This trial tests whether repeatedly inflating a blood pressure cuff on the upper arms to 200 mmHg for short cycles can trigger protective molecular changes in the blood of healthy adults aged 18 to 45. Participants are randomly assigned to receive the cuff cycles either once or t…