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Simple arm cuff routine may unlock Heart-Protective signals in the blood

NCT ID NCT05957523

Knowledge-focused Sponsor: First Affiliated Hospital Xi'an Jiaotong University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial tests whether repeatedly inflating a blood pressure cuff on the upper arms to 200 mmHg for short cycles can trigger protective molecular changes in the blood of healthy adults aged 18 to 45. Participants are randomly assigned to receive the cuff cycles either once or twice daily for 40 minutes. Researchers will measure changes in cardiovascular-related molecules and blood pressure to explore how this simple physical stimulus might protect the heart and blood vessels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote ischemic preconditioning via automated blood pressure cuff cycles (200 mmHg, 5 min on/5 min off, 4 cycles, once or twice daily)
What this could lead to
If it works, this could reveal a simple, non-drug way to prime the body against heart and blood vessel injury.
What could go wrong
This is an early, small study in healthy adults, so results may not apply to people with disease. The effect on real-world heart attacks or strokes is not yet tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 to 45 years; * Be in good health; * Consent to participate in the clinical trial and sign the informed consent form. Exclusion Criteria: * Abnormal results in biochemical checks and physiological indicators. * Cardiovascular and cerebrovascular diseases: hypertension, coronary heart disease, congenital heart disease, cerebrovascular alterations, etc. * Endocrine diseases: diabetes, thyroid disorders, etc. * Hematologic diseases: anemia, paroxysmal hemoglobinuria, primary thrombocytosis, etc. * Infectious diseases: hepatitis B, hepatitis C, syphilis, etc. * Cancer. * Neurological and psychiatric disorders. * Vascular diseases: peripheral vascular disease, Raynaud's syndrome, thromboembolic diseases. * Major trauma or surgery within the last six months. * Pregnant or breastfeeding women. * Upper limbs unsuitable for compression treatment: history of upper limb surgery, presence of tissue damage and limb deformity, and concomitant hemorrhagic diseases. * Recent circumstances that may affect results: blood donors within the last month, any medication taken within the last month, fever within the last week, women within their menstrual cycle or within 7 days before the start of menstruation. * Patients who refuse to sign the informed consent form for participation in this study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic preconditioning

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • First Affiliated Hospital of Xian Jiantong University

    RECRUITING

    Xi'an, Shaanxi, 710061, China

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