Eli Lilly And Company

This early-stage study tests an experimental drug called LY4174794 in 108 healthy volunteers who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to measure weight loss. Participants will receive either the drug or a p…

This early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…

This study tests a new drug called imlunestrant in 600 premenopausal women with estrogen receptor-positive, HER2-negative breast cancer. Some women will also receive ovarian suppression. The goal is to see how the drug affects cancer cells and the ovaries compared to tamoxifen. T…

This study tests whether two experimental drugs, macupatide and eloralintide, taken alone or together, can help adults with obesity or overweight lose weight safely. About 400 participants will receive either the drugs or a placebo for around 64 weeks. The main goal is to see how…

This study looks at the long-term safety of an experimental drug called LY4256984 for people with amyotrophic lateral sclerosis (ALS). It is an extension of an earlier study and will follow 32 participants for about 96 weeks. The main goal is to track any serious side effects rel…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This early-stage study tests a new drug called LY4152199 in adults with B-cell cancers (like certain lymphomas) that have come back or not responded to prior treatments. The drug is designed to help the body's immune cells attack cancer cells. The main goals are to find the safes…

This study looks at whether people with Alzheimer's who have already taken donanemab benefit from getting it once a year. About 550 participants will be followed for up to 2.5 years to see if their thinking and memory stay stable. The goal is to find a convenient way to manage th…

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This study tests a new, non-invasive eye scan that uses artificial intelligence to look for changes linked to Alzheimer's disease. Researchers will compare the scan results with blood tests in 200 UAE adults who have mild memory problems. The goal is to see if this quick, painles…

This study tests whether the drug donanemab can delay memory and thinking problems in Chinese adults who are at risk for Alzheimer's disease. About 140 participants with normal thinking skills but signs of brain changes will receive either donanemab or a placebo through an IV eve…

This Phase 2 trial tests an oral drug called LY4065967 for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed arthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity over time.

This study tests a new medicine called LY4065967 for people with long-term low back pain. About 150 adults will receive either the drug or a placebo to see if it safely reduces pain and improves sleep. The goal is to find better treatment options for chronic pain.

This study will measure the amount of mirikizumab, a drug for inflammatory bowel disease, in the breast milk of 14 breastfeeding women who are already taking it. The goal is to see how much of the drug passes into milk, which can help guide safe use during breastfeeding. Particip…

This early-stage study will test how eltrekibart, an experimental drug, is absorbed when injected under the skin compared to when given through a vein. Sixty healthy adults will receive a single dose and be monitored for about 17 weeks. The goal is to gather safety and absorption…

This study tests if a simple headband worn at home can measure sleep stages as accurately as a full sleep lab test in people with early or no Alzheimer's symptoms. About 35 participants will wear both devices at the same time for two nights in a lab, then use the headband alone a…

This study checks the long-term safety of experimental treatments for amyotrophic lateral sclerosis (ALS). It enrolls 32 people who finished an earlier ALS drug study and will follow them for at least 96 weeks. The main goal is to see how many participants can be assigned to each…