Duke University

This study tests a drug called inclisiran to lower LDL (bad) cholesterol in 130 people with heart disease or high risk for it. It focuses on groups like women, Black, Hispanic, and rural patients who often don't get enough treatment. The goal is to see if inclisiran helps them re…

This study tests whether a single, strong dose of radiation given before surgery can safely treat early-stage breast cancer while keeping the breast looking and feeling good. About 110 women with small, localized breast tumors will receive 21 Gray of radiation in one session, the…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce cannabis use and cravings in heavy users. Fifty near-daily cannabis users will receive either real or placebo TMS over two weeks. The researchers will track changes in cannabis use and brain…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better control high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these heart-related conditions will take par…

This study looks at whether giving a lower dose of radiation (20 Gy instead of 30 Gy) to a smaller area can still keep lymphoma from coming back in patients who had a good response to chemotherapy. About 241 adults with diffuse large B-cell lymphoma will take part. The goal is to…

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan uses tube feeding, oral supplements, and a device to measure calorie needs. Researchers will track infections, hospital stay length, and muscle changes to…

This study tests whether drinking a ketone supplement for 8 weeks can improve exercise ability in people with a type of heart failure called HFpEF. Twenty adults with stable heart failure will try both the ketone drink and a placebo drink at different times, without knowing which…

This study tests whether a faster form of brain stimulation (accelerated TMS) can improve hand function in people with focal hand dystonia, a condition causing involuntary muscle contractions during tasks like writing. Twenty-one adults will receive four TMS sessions in one day, …

This study tests different treatments for sleep problems caused by Long COVID. About 361 adults with sleep issues like daytime sleepiness or insomnia will receive a treatment matched to their specific sleep problem. The goal is to see if these treatments can improve sleep and red…

This study is testing different treatments to help people with Long COVID who have trouble sleeping. About 470 adults will join, and researchers will use sleep trackers and surveys to see if the treatments improve sleep and reduce daytime tiredness. The goal is to find safe, effe…

This study tests whether a noninvasive brain stimulation technique called TMS, guided by fMRI brain scans, can improve neck muscle control in people with cervical dystonia. Fifty adults with the condition will receive four TMS sessions in one day, and researchers will measure cha…

This study tests whether advanced brain imaging can help doctors target deep brain stimulation more precisely to control tremor in Parkinson's disease while avoiding unwanted movements. About 20 adults who already have a DBS device will use an iPhone app to track their symptoms. …

This study explores whether playing virtual reality games can help adults in the intensive care unit move their arms and hands more, and improve feelings of anxiety, depression, or loneliness. About 30 people who have been in the ICU for at least 3 days and have trouble moving wi…

This study is testing a new scoring system called the 5-SENSE score to see if it can accurately predict where seizures start in the brain for people with hard-to-treat epilepsy. The goal is to help doctors decide who truly needs an invasive test called SEEG, which involves placin…

This study was designed to see how consistently MRI scans measure tumor changes in people with a slow-growing brain tumor (IDH1-mutant low-grade glioma) who are taking the drug ivosidenib. It planned to enroll adults aged 18–70 actively receiving the drug at Duke University. Howe…

This study compares a new, low-cost eye scanner to a standard one to see if it can take clear pictures of the retina. Researchers will also test if the device can measure retinal changes linked to Alzheimer's disease. About 82 adults, including some with mild Alzheimer's, will pa…

This study planned to test a new robotic system that helps doctors take detailed 3D pictures of the far edges of the retina, an area that is hard to see with standard eye scanners. It was designed for healthy adults over 18 with no known eye problems. However, the study was withd…

This study aimed to see if limiting eating to a 10-hour window each day could improve how well immunotherapy works in people with advanced head/neck or kidney cancers. Researchers planned to track changes in gut bacteria and immune responses, with a special focus on African Ameri…

This study is a registry that collects information from 900 people with spine tumors, infections, instability, or injuries. Researchers will review medical records, ask about quality of life, and collect tissue and blood samples during surgery. The goal is to learn more about the…

This study aims to improve safety for astronauts during spacewalks by testing a method to prevent decompression sickness, also known as "the bends." Twelve healthy volunteers, ages 18 to 50, will breathe pure oxygen for 6 hours and then spend 6 hours in a low-pressure chamber to …

This study looks at whether stroke patients who do high-intensity rehabilitation at home recover their physical function as well as those who go to an inpatient rehab facility. Researchers will follow 500 patients who choose home rehab after leaving Duke University Hospital. The …

This study was designed to see if training obstetric providers (doctors, nurses, etc.) on workplace rights and accommodations helps pregnant patients get better support at work. Researchers planned to compare counseling rates, wage changes, and health outcomes between providers w…

This study is building a registry of 20,000 people living in the United States who are interested in taking part in future research on COVID-19 and other health issues. Participants sign up online and provide their email address to receive updates about upcoming studies and healt…

This study is a registry that tracks people with ocular melanoma (a type of eye cancer) who receive a radiation treatment called plaque brachytherapy. The goal is to see if using lower doses of radiation can still effectively control the cancer while causing fewer side effects. T…

This study tests whether a special type of MRI (using xenon gas) can measure how well anti-fibrotic medications work in people with progressive lung scarring. About 60 adults with certain types of interstitial lung disease will have MRI scans before starting treatment and again a…

This study was designed to learn how body weight changes the way etanercept works in people with rheumatoid arthritis or juvenile idiopathic arthritis who are also obese. Researchers planned to measure drug levels and disease activity in both adults and children starting the medi…

This study follows about 468 people with advanced kidney cancer to see how their treatment and quality of life change over time in real-world settings. Researchers will collect information from patients, doctors, and medical records to understand what treatments are used and how …