Children's National Research Institute

This early-phase study tests whether specially trained donor immune cells (TAA-T cells) are safe for children with high-risk solid tumors like neuroblastoma, sarcoma, or Wilms tumor that have come back or not responded to standard treatments. Up to 36 participants will receive ce…

This early-phase study tests whether a personalized immune cell treatment is safe for children under 5 with certain brain tumors. The treatment uses the child's own immune cells, trained to attack unique markers from their tumor. Up to 12 children will receive the therapy after s…

This early-phase study tests a new drug (SGT-53) combined with radiation and immunotherapy (Nivolumab) for children whose brain tumors have returned or not responded to standard treatments. The goal is to find a safe dose and understand side effects. Up to 18 children with specif…

This early-stage trial tests a new treatment using the body's own immune cells (T cells) that are specially trained to attack cancer. It is for children with certain cancers (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, or Wilms tumor) that have come back or not responded to s…

This early-stage study tests whether giving specially grown immune cells (T-cells) that target norovirus is safe for people with weakened immune systems, such as those who had a stem cell or organ transplant. The therapy aims to help the body fight off a chronic norovirus infecti…

This study tests whether giving a drug called daratumumab before a stem cell transplant can prevent a serious complication where the body attacks donor red blood cells. It includes children and young adults (ages 2-24) with sickle cell disease who have a matched sibling donor. Pa…

This early-stage study tests whether special immune cells (T cells) from a donor can prevent COVID-19 in people who recently had a stem cell transplant and have weak immune systems. About 24 adults and children will receive one of three doses of these cells. The main goal is to c…

This study tests whether a short-term therapy for depression, called Enhanced IPT-B, can help Black mothers of children with asthma feel better and possibly improve their child's asthma. About 60 mothers will receive either the therapy or standard care plus extra support. The goa…

This study tests whether an augmented reality (AR) system can safely help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure (like a biopsy or injection) will take part. The main goal is to see if the AR system works in at least 80% o…

This study aims to create a simple, objective tool to detect nerve damage caused by the chemotherapy drug vincristine in children and teens. By using a device that measures pupil reactions, researchers hope to catch nerve problems earlier than current methods allow. The study wil…

This study aims to create a new, objective way to measure pain in children with juvenile idiopathic arthritis, lupus, or fibromyalgia. Researchers will collect data from 90 participants over one year to see if this pain measurement can help doctors choose the right treatment fast…

This study is building a worldwide registry of children, teens, and young adults with rare brain tumors. Researchers will collect tumor samples and medical information to learn more about these cancers and find better ways to treat them. The goal is to improve understanding, not …

This study tests whether a digital sexual health survey can help doctors spot more sexually transmitted infections (STIs) in teens aged 15-21 visiting the emergency department. Researchers will compare STI detection rates when the survey is used versus standard care. The goal is …

This study is testing a new, non-invasive device that measures pain in children and teens by tracking changes in pupil size. Researchers want to see if it can provide a more objective way to assess pain than current methods. The study will include 100 participants ages 6 to 21 wh…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…