Children's Hospital Of Orange County

This study tests the drug fenfluramine in children aged 12 to 36 months whose infantile spasms have not improved with standard treatments. Over 21 days, researchers will check if the drug stops the spasms and improves brain wave patterns. Children who respond well may continue tr…

This study tests a drug called suramin (KZ101) to see if it can improve social skills in boys aged 5-14 with autism. The trial will involve 45 participants and uses a crossover design, meaning each boy will receive both the drug and a placebo at different times. The main goal is …

This study tests a small device that sends gentle electrical pulses to nerves in the ear to see if it can reduce pain and other symptoms in children with post-concussion syndrome or long COVID. About 125 children ages 11-18 will take part. The goal is to improve their daily funct…

This study tests whether real acupuncture can reduce stomach pain and improve daily life for children aged 8-17 with disorders of gut-brain interaction, like irritable bowel syndrome. Half the 96 participants will get real acupuncture, the other half a sham (fake) treatment, alon…

This study looks at how heart and blood vessel problems develop in people with MPS types I and IVA. Researchers will use yearly ultrasounds, blood draws, and urine tests for 4 years to track changes and find markers that could guide future treatments. The study involves 240 parti…