Centre Hospitalier Universitaire De Besancon

This study tests whether adding a cancer vaccine (UCPVax) with or without an immunotherapy drug (pembrolizumab) to standard treatment can help people with a fast-growing type of glioblastoma live longer. About 98 adults with newly diagnosed, unmethylated MGMT glioblastoma will ta…

This study looks at whether doing an early belly ultrasound can help doctors diagnose serious gut problems in premature babies. About 100 premature infants with symptoms like bloating, bleeding, or vomiting will get an early ultrasound. The goal is to see if this scan, along with…

This study aims to see if a simple saliva swab can find genetic causes of neurodevelopmental or intellectual disorders that standard blood tests miss. About 50 people with these conditions whose blood tests were inconclusive will provide a cheek swab for deep genetic analysis. If…

This study looks at whether adding real-time weather and air pollution information to a standard clinical checklist can help emergency room doctors more quickly identify acute aortic syndrome (AAS), a life-threatening tear in the body's main artery. Researchers will review medica…

This study looks at whether giving a drug called dapagliflozin (a gliflozin) early in the emergency room can help elderly patients (75 and older) who are hospitalized for worsening chronic heart failure. The trial will include 144 participants across 6 hospitals. The main goal is…

This study looks at whether a tailored exercise program can help muscle cells recover oxygen faster after activity in menopausal women with major depression. Researchers will measure muscle oxygen levels using a light-based device before and after an 8-week program. The goal is t…

This study looks at whether a special ultrasound score called VExUS can help doctors measure vein congestion in patients in the intensive care unit (ICU). Doctors often give fluids to treat shock, but too much fluid can harm veins and organs. The study will include 525 adult ICU …

This study looks at how well the DPD enzyme works in people with cancer and/or kidney failure. The DPD enzyme breaks down common chemotherapy drugs, and low activity can cause severe side effects. Doctors currently use a blood test to check DPD function, but kidney problems may m…