Centre Francois Baclesse

This study is for people with kidney cancer that has spread and is starting to grow again in just a few places while on standard drug therapy. Instead of switching to a new drug right away, doctors will use precise, high-dose radiation (stereotactic radiotherapy) to target only t…

This study tests whether a combination of two drugs (Talazoparib and Avelumab) can help keep advanced urothelial (bladder) cancer from growing after initial chemotherapy. About 50 adults with cancer that has spread will receive this maintenance treatment. The goal is to see if it…

This study tests whether weekly digital symptom reports from patients with advanced kidney cancer can help doctors make timely adjustments to their treatment with cabozantinib and nivolumab. About 83 adults starting this combination therapy will use a digital platform to report s…

This study tests whether a new radiation technique that avoids the surgical flap can reduce side effects without increasing cancer recurrence. It includes 348 adults with oral cavity cancer who had reconstructive surgery with a flap. Participants will receive either flap-sparing …

This study compares two ways of delivering high-dose radiation to people with a limited number of brain metastases (up to 5 tumors). One method gives a single large dose, while the other splits the dose into three smaller sessions. The goal is to see which approach better control…

This study is for people with intermediate-risk differentiated thyroid cancer. It compares two approaches after surgery: giving radioactive iodine (RAI) to everyone, or only giving it based on follow-up tests. The goal is to see if the guided approach works just as well while avo…

This study tests two ways to cool the scalp during chemotherapy to prevent hair loss in women with early-stage breast cancer. About 196 participants will receive either a standard cooling cap or a cooling mask while getting anthracycline and taxane chemotherapy. The goal is to se…

This study tests whether a remotely supervised online cognitive stimulation program can reduce memory and thinking complaints in breast cancer patients who have finished chemotherapy. About 300 participants will either get the supervised program or do unsupervised brain exercises…

This study looks at whether special beauty and skincare sessions (called adapted oncoesthetics) can help people with head and neck cancer feel better about their appearance after treatment. About 55 patients will try these sessions early in their care. The goal is to see if this …

This study looks at whether a special day-hospital visit with a team of experts can help women who finished treatment for ovarian or endometrial cancer get the supportive care they need. About 268 women in remission will either receive a personalized care plan with a day-hospital…

This study looks at whether using a walking platform every day can help people aged 65 and older regain their normal walking speed after cancer surgery. About 60 participants will use the platform during their hospital stay. The goal is to see if this simple activity helps them r…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can improve quality of life by reducing digestive problems like nausea and bloating during first-line chemotherapy for ovarian cancer. About 116 women will be randomly assigned to receiv…

This study takes tumor samples from 120 people with head and neck cancer and grows them in the lab as mini tumors called organoids. Researchers will test different treatments on these organoids to see which ones work best, with the goal of choosing the most effective therapy for …

This study looks at how sleep troubles impact memory, focus, and quality of life in women treated for breast cancer. Researchers will track sleep patterns using a wrist monitor and ask participants about their thinking and well-being. The goal is to better understand these links …

This study looks at 88 women with advanced ovarian cancer to compare two tests that check for DNA repair problems (HRD status). The goal is to see if the test results match how well the cancer responds to standard platinum chemotherapy. If a test shows a repair problem, a PARP in…

This study looks at two types of radiation for a slow-growing brain tumor near important brain areas. It compares proton therapy with standard photon radiation to see which causes fewer long-term problems with memory, thinking, and vision. About 160 adults aged 18 to 70 with this…

This study takes small tumor samples from 163 people with early-stage triple-negative breast cancer and grows them in the lab as 3D mini-tumors called organoids. Researchers will test different cancer drugs on these organoids to see which ones work best and look for biological ma…

This study takes tumor and blood samples from 20 people with a rare, hard-to-treat cancer called undifferentiated carcinoma. Researchers will grow mini-tumors (organoids) in the lab to see if they can predict which treatments will work best for each patient. The goal is to learn …