Biontech Se

This study is testing a new version of the COVID-19 vaccine that is designed to work better against newer virus variants. It includes over 4,000 healthy children from 6 months to 12 years old, some who have had prior COVID-19 vaccines and some who have not. The goal is to see if …

This early-stage trial tests an investigational vaccine designed to prevent genital herpes lesions caused by HSV-2 (and possibly HSV-1). About 318 adults aged 18–55 will receive different doses of the vaccine or a placebo to check safety and immune response. The study is active b…

This study tests two experimental vaccines (BNT164a1 and BNT164b1) to prevent tuberculosis (TB) in adults who have already received the BCG vaccine and are HIV-negative. About 497 participants will receive up to three doses to find the safest and most effective dose. The goal is …

This study tests an updated COVID-19 vaccine designed for the 2025-2026 season in people 12 and older who are at higher risk of severe illness, including those 65+. About 760 participants will receive one shot and be monitored for safety and immune response over 6 months. The goa…

This study tests an updated COVID-19 vaccine (2025/2026 formula) in 343 children aged 5 to 11 who have health conditions that put them at high risk for severe COVID-19. Each child receives one shot and is followed for about 6 months to check safety and immune response. The goal i…

This study tests whether an updated COVID-19 vaccine can safely protect healthy adults aged 50 to 64 from the virus. About 5,240 participants will receive either the variant-adapted vaccine or a placebo. Researchers will monitor side effects and track how many people get COVID-19…

This study tests an experimental mRNA vaccine (RO7198457) in people with stage II or III colorectal cancer who have a positive ctDNA blood test after surgery, meaning they are at high risk for the cancer coming back. Participants are randomly assigned to receive the vaccine or to…

This study tests a new drug called BNT327 combined with chemotherapy for people with a hard-to-treat type of lung cancer (small-cell lung cancer). About 110 adults with either newly diagnosed or previously treated cancer will take part. The goal is to see if the combo shrinks tum…

This study tests a new drug called BNT327, given together with chemotherapy, for people with advanced triple-negative breast cancer that has spread. The goal is to see if the combination is safe and shrinks tumors. About 83 adults will take part, receiving one of two dose levels …

This study is the first to test BNT314 in humans. It aims to see if the drug is safe when given alone to people with advanced solid tumors that have not responded to other treatments. About 41 participants will receive different doses to find the highest dose that is still safe a…