Bicycletx Limited

This study tests an experimental drug, zelenectide pevedotin, in people with advanced non-small cell lung cancer that has a specific genetic change called NECTIN4 amplification. Participants must have already tried at least one prior cancer treatment. The goal is to see if the dr…

This study tests a new drug called BT8009, given alone or with another drug (pembrolizumab), in people with advanced solid tumors like bladder, breast, lung, or ovarian cancer that have not responded to standard treatments. The goal is to see if the drug is safe and can shrink tu…

This study tests a new drug called BT7480, alone or with another drug (nivolumab), in people with advanced solid tumors that have not responded to standard treatments. The goal is to find a safe dose and see if it can shrink tumors or slow their growth. About 200 participants wil…

This study tests an experimental drug called BT5528, given alone or with another drug (nivolumab), in people with advanced solid tumors that have high levels of a protein called EphA2. The cancers include ovarian, bladder, lung, breast, head and neck, and stomach cancers. The mai…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced bladder cancer that has spread. About 956 participants will be split into two groups: those who haven't had treatment yet and those who have tried other therapies. The g…

This study tests an experimental drug, zelenectide pevedotin, in people with advanced breast cancer that has a specific genetic change called NECTIN4 amplification. The trial includes two groups: one with hormone receptor-positive/HER2-negative cancer and another with triple-nega…