Baylor Research Institute

This study tested a weight loss program designed specifically for adults with long-term spinal cord injuries. The program combined three approaches: portion-controlled meals, self-monitoring tools, and lifestyle coaching. Researchers aimed to find the best combination to help peo…

This study tested whether having patients breathe in nitric oxide gas during a liver transplant could protect the new organ from damage. The research focused on transplants using 'marginal' donor livers, which are at higher risk of injury. Doctors compared outcomes between patien…

This small, early-stage study aimed to see if it was safe to add a drug called anakinra to standard chemotherapy for people with advanced pancreatic cancer that had spread. Anakinra is an anti-inflammatory drug approved for rheumatoid arthritis. Researchers wanted to check for si…

This study tested whether a group lifestyle and weight loss program, specially adapted for people with mobility disabilities, was effective. Researchers compared people who started the program right away to those who waited six months. They measured changes in weight, physical ac…

This study tested different ways to help doctors provide better care for older adults with diabetes. Researchers gave some doctors feedback reports on their patients' test results and care, while other clinics also received a dedicated diabetes nurse to help coordinate care. The …

This study tested whether a weekly injection of the diabetes medication exenatide could help protect the heart and kidneys in people with type 2 diabetes who were at risk for heart problems and had mildly reduced kidney function. For 38 weeks, some participants received the real …

This study compared two different techniques for closing the artery in the groin after a minimally invasive heart valve replacement procedure. Researchers wanted to see if using two special stitches was as safe as using one stitch plus a plug. They measured which method led to fe…

This study tested whether pairing people with a community health worker for 10 months could help them better manage chronic health conditions like diabetes, high blood pressure, and obesity. The program provided navigation help to access health services, education, and support fo…

This study tested if a new, once-daily version of a common anti-rejection drug works as well as the standard twice-daily version for heart transplant patients. It involved 50 adults who had received a heart transplant. The main goal was to see if the simpler, once-a-day pill was …

This study tested a device called the Lariat to tie off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to prevent strokes in patients who cannot safely take standard blood-thinning medications. Doctors performed the procedure on a…

This study compared two imaging methods used to fix blocked dialysis access tubes. Researchers tested whether adding an ultrasound probe (IVUS) to the standard x-ray dye method (angiography) gave better results during repair procedures. The trial involved 66 patients whose dialys…

This study tested if giving hospitalized COPD patients a strong, once-daily combination inhaler could help them recover better. Researchers wanted to see if this approach reduced the need for extra breathing treatments, shortened hospital stays, and lowered the chance of being re…

This study tested if adding a very low-carbohydrate diet to standard care could help lower blood pressure in lower-income African American adults. It involved 64 participants with high blood pressure or risk factors for heart disease. The main goal was to see if this specific die…

This study aimed to validate a new Spanish-language digital screening tool for identifying tobacco, alcohol, prescription drug, and illicit substance use in primary care settings. It involved 1,000 adult patients who preferred Spanish. Researchers tested how well the new tool's r…

This study aimed to find a more accurate way to measure kidney function in people with advanced liver disease (cirrhosis). Researchers compared a newer blood test (cystatin C) and standard tests against a precise, specialized measurement. The goal was to see if the newer test cou…

This study aimed to find markers in blood that could lead to an early detection test for a serious type of ovarian cancer. Researchers analyzed tissue and blood samples from 10 women with undiagnosed pelvic masses. The goal was to identify specific DNA changes that signal the pre…

This study tested a special ultrasound machine that measures liver stiffness without surgery. Researchers wanted to see if this painless scan could replace invasive liver biopsies for diagnosing liver disease and monitoring heart failure patients. The study involved over 1,200 ad…

This study tested whether a special bandage coated with silver could prevent serious bloodstream infections in very small, premature babies who need IV lines. Researchers compared the silver bandage to standard bandages in 100 infants to see if it reduced infections. They also ch…

This study tested whether a specific talk therapy could help people with spinal cord injuries who also have post-traumatic stress disorder (PTSD). Researchers enrolled 30 participants and randomly assigned them to either receive the new therapy or continue with their usual care. …

This study tested if giving a long-acting numbing medicine before making the chest incision for heart surgery helps reduce pain afterward. Researchers compared this approach to a placebo in 70 patients to see if it lowered pain scores and reduced the need for strong opioid painki…

This study compared two types of flexible epidural catheters used for pain relief during labor and delivery. Researchers wanted to see if catheters with multiple medication ports provide better pain control than those with a single port. The study involved 650 pregnant women in l…

This study tested whether a 12-week harmonica training program could help people with COPD. Fifteen participants learned to play the harmonica in group classes and practiced at home, aiming to strengthen their breathing muscles. Researchers measured if this musical activity reduc…

This study aimed to understand the genetic causes of early-onset Alzheimer's disease. Researchers collected blood samples from 26 people with the condition and their family members. They analyzed DNA and RNA to identify biological markers that could help diagnose and treat the di…

This study aimed to see if a new type of lab test could predict which liver transplant patients were more likely to reject their new organ. Researchers tested 221 people who had received a liver transplant. The goal was to learn if patterns in a patient's genes could act as an ea…

This study tested a simple electrical measurement to track body composition changes in 69 patients after a heart transplant. Researchers wanted to see if this measurement could better predict recovery problems like rejection or infection compared to older methods like BMI. The go…

This study aimed to discover new signs in blood and urine that could help detect Alzheimer's disease earlier. Researchers analyzed samples from 95 people, including those with normal memory, mild thinking problems, and different stages of Alzheimer's. The goal was to find pattern…

This study aimed to understand why people with spinal cord injuries (SCI) often gain weight after leaving the hospital. Researchers followed 42 adults with recent SCI for one year after their rehab stay, checking in at discharge, 6 months, and 12 months. They collected informatio…

This study aimed to understand if and how a common heart valve replacement procedure (TAVR) affects memory and thinking skills in patients who already have mild cognitive impairment. Researchers followed 81 patients, testing their memory before the procedure, then 30 days and 6 m…

This study followed up with five adults who have Fabry disease, a rare genetic disorder, to see how they are doing after receiving enzyme replacement therapy (ERT) since childhood—about 15 years total. Researchers checked their kidney and heart function, pain levels, and quality …

This study aimed to understand how doctors manage blood-thinning medications for heart patients who need surgery. Researchers observed 147 patients to see what strategies were used and track the risks of bleeding or heart problems. The goal was to gather real-world data to help d…

This study aimed to understand how social and economic factors—like income, stress, and depression—affect heart and blood vessel health in minority communities at higher risk for health disparities. Researchers enrolled 105 adults to complete surveys about their life experiences,…

This study tested whether adding a continuous breathing rate monitor to the standard oxygen and heart rate monitors could help detect breathing problems earlier. Researchers observed 87 adults who had surgery and were on opioid pain medication. The new breathing data was collecte…

This study aimed to understand why some people with a specific heart valve condition develop dangerous bulges in their main artery, called aortic aneurysms. Researchers collected blood and tissue samples from 91 adults who were having heart valve surgery. By analyzing the genetic…

This study aimed to discover genetic markers that could help identify people at risk for severe bleeding after childbirth, known as uterine atony. Researchers compared small tissue and blood samples from 21 people who experienced this condition with those who did not. The goal wa…