Bayer

This study tested the safety of an extended-release clotting factor injection called BAY94-9027 (Jivi) in children aged 7-12 with severe hemophilia A. The treatment is designed to last longer in the body, potentially requiring fewer injections to prevent and control bleeding epis…

This large study tested whether a daily pill called finerenone could slow the worsening of kidney disease in people who do not have diabetes. About 1,580 adults took either finerenone or a placebo (a dummy pill) for up to four years, while continuing their usual kidney medication…

This study checked how much of a high-dose eye medication gets into the bloodstream when injected into both eyes. Researchers gave 51 adults with diabetic macular edema or age-related macular degeneration injections in both eyes and measured drug levels in their blood. The goal w…

This study tested if a higher dose of an existing eye injection (aflibercept 8 mg) could control vision loss from macular edema as effectively as the standard dose, but with fewer injections. It involved 892 adults with swelling in the center of the eye caused by a blocked retina…

This study tested whether adding a new drug called darolutamide to standard hormone therapy and chemotherapy could help men whose prostate cancer had spread. Over 1,300 participants received either darolutamide or a placebo pill twice daily, along with their standard treatments. …

This study monitored the safety and effectiveness of Kovaltry, a medication for hemophilia A, during routine medical use. Researchers followed 230 patients, including 50 children under 12, for up to two years to track side effects and how well the drug controlled bleeding episode…

This study tested if a new drug, BAY 3018250, could dissolve dangerous leg blood clots (deep vein thrombosis) faster and more effectively than standard blood thinners. 258 adults with recent leg clots received either a single dose of the new drug or a placebo, alongside their usu…

This study followed 100 babies for several years after they received treatment for retinopathy of prematurity (ROP), an eye disease affecting premature infants. The main goal was to see how their vision, eye health, and overall development turned out long-term. Researchers checke…

This study tested a new scoring system to help doctors personalize treatment plans for people with hemophilia A when switching to a longer-lasting medication called Jivi. The score used factors like a person's bleeding history and activity level to assign one of three dosing sche…

This study collected real-world data to see how well the heart failure drug vericiguat works compared to standard treatments for Chinese patients. It followed 2,400 adults with a weakened heart who had recently been very sick. The main goal was to see if the drug could help patie…

This study tested how well the drug larotrectinib works against advanced solid tumors that have a specific genetic change called an NTRK fusion. It involved 215 adults with various cancer types who had already tried standard treatments. Larotrectinib is designed to block the abno…

This study tested whether people with chronic heart failure could safely start taking the medication vericiguat at a higher dose than usual. Researchers wanted to see if starting at 5 mg instead of 2.5 mg would help patients reach the full 10 mg treatment dose faster, potentially…

This large, completed Phase 3 trial tested whether adding a new drug called copanlisib to the standard treatment rituximab was better at delaying the return or worsening of cancer in patients with a slow-growing type of non-Hodgkin's lymphoma that had come back. It involved 458 a…

This study aimed to collect more safety information about an approved eye injection (aflibercept) for diabetic macular edema (DME) specifically in Indian patients. DME is a diabetes complication where fluid leaks into the retina, causing vision loss. Over 52 weeks, researchers mo…

This study tested whether a small tablet that sticks to the gum (Sitavig) helps cold sores heal faster than a dummy tablet. Adults who get frequent cold sores applied one tablet at home when they felt a sore starting. Researchers tracked how long it took sores to heal completely …

This study tested whether adding the medication finerenone to standard care could better protect kidney function in adults with both chronic kidney disease and type 1 diabetes. Researchers compared finerenone against a placebo (inactive pill) in 241 participants over 6 months of …

This study looked back at health records to see how well a heart failure medicine called vericiguat works for people in everyday German medical care. Researchers analyzed data from 500 adults with chronic heart failure who were newly prescribed the drug between 2021 and 2023. The…

This study followed over 1,400 men with advanced prostate cancer that had spread to their bones to monitor the long-term safety of the treatment Radium-223. Researchers tracked serious side effects, bone marrow health, and the risk of developing a second, unrelated cancer for up …

This early-stage study tested the safety of a new oral drug, BAY3283142, in people with high blood pressure and chronic kidney disease. The drug is designed to relax blood vessels. For 10 weeks, 75 participants took either the drug or a placebo pill, and researchers monitored the…

This study tested whether adding a new drug called darolutamide to standard hormone therapy helps men whose prostate cancer has spread. It involved 669 men and compared the combination to hormone therapy alone. The main goal was to see if the new combination could delay the cance…

This early-stage study tested a new oral drug called BAY2862789 in 45 people with advanced solid tumors that had stopped responding to standard treatments. The drug works by activating the body's own immune T-cells to fight cancer. Researchers primarily wanted to determine safe d…

This first-in-human study tested the safety and effects of an oral drug called larotrectinib in adults with advanced solid tumors that have a specific genetic change (NTRK fusion). The trial involved 75 patients for whom other effective therapies did not exist. Researchers aimed …

This study allowed patients with pulmonary arterial hypertension (PAH) who had previously taken riociguat in Bayer clinical trials to continue receiving the medication long-term. The main goal was to monitor the drug's safety and side effects over an extended period. Only 18 pati…

This study compared two prostate cancer drugs, darolutamide and enzalutamide, to see if one causes fewer side effects like breast tenderness and tissue growth. Researchers tested 28 men whose prostate cancer had returned after initial treatment but hadn't spread significantly. Th…

This large, completed Phase 3 trial tested whether adding a radioactive drug called Radium-223 to standard care could help men with advanced prostate cancer that had spread to their bones and was no longer responding to hormone therapy. The main goal was to see if the treatment h…

This study tested a new contrast agent called gadoquatrane for MRI scans of the body (excluding the brain and spine). Researchers wanted to see if this new agent, which uses a lower dose of the metal gadolinium, could produce images as good as or better than the standard contrast…

This large, completed Phase 3 trial tested whether a new oral blood thinner called asundexian could prevent future strokes in over 12,000 people who had recently suffered a stroke or a high-risk mini-stroke (TIA). Participants took either asundexian or a placebo pill daily for up…

This study observed 1,500 women to understand how different vitamin supplement plans, taken before and during pregnancy, affect health outcomes for mother and baby. Researchers specifically tracked rates of common complications like anemia, preeclampsia, and low birth weight. The…

This study tested whether a new drug called elinzanetant could reduce hot flashes in women after menopause. Researchers compared it against a placebo (dummy pill) in 396 postmenopausal women who experienced frequent moderate-to-severe hot flashes. Participants took daily capsules…

This study tested whether a new drug called elinzanetant could reduce hot flashes in postmenopausal women. Researchers compared it to a placebo in 628 women over 52 weeks, tracking how many hot flashes they had and how severe they were. The study also looked at whether the treatm…

This study tested whether a new medication called elinzanetant could improve sleep for women experiencing nighttime awakenings during menopause. Researchers compared elinzanetant against a placebo in 110 participants over 12 weeks, measuring sleep quality through overnight sleep …

This study tested whether a new drug called elinzanetant could safely reduce the number and severity of hot flashes in women after menopause. 400 postmenopausal women with frequent moderate-to-severe hot flashes took either elinzanetant or a placebo pill daily for up to 26 weeks.…

This study aims to better understand how sleep problems affect women going through menopause. Researchers will observe 750 women using smartwatches and questionnaires to track their sleep patterns and current treatments. The goal is to gather information that could lead to better…

This study aimed to understand how the body absorbs new pill versions of an experimental drug called elinzanetant, which is being developed to treat hot flashes. Researchers compared how much of the drug got into the bloodstream from a new capsule form versus the original form. T…

This study aimed to understand how the cancer treatment Radium-223 spreads in the bones of men with advanced prostate cancer that has spread to bone. Researchers enrolled 46 men and divided them into two groups based on the number of bone tumors. Participants received up to six i…

This study looked back at the medical records of 818 adults in the U.S. with advanced colorectal cancer that had spread. Researchers wanted to understand if taking the drug regorafenib first, followed by TAS-102 (with or without bevacizumab), or the reverse order, led to better r…

This study aims to understand how liver disease changes the way the body processes an experimental cancer drug called sevabertinib. Researchers compared about 20 people—half with moderate liver problems and half with healthy livers—after each took a single dose. By measuring drug…

This study looked at existing medical records to understand if the order in which patients receive certain cancer treatments affects how long they live. Researchers examined data from 121 people in Europe with advanced colorectal cancer who had already tried multiple treatments. …

This study looked back at existing medical records to learn how a heart failure drug called vericiguat is used and what happens to patients in real-world Japanese clinics and hospitals. Researchers analyzed data from nearly 5,000 adults with chronic heart failure who started taki…

This study analyzed existing medical records from over 5,700 adults in Japan who had sepsis, a life-threatening blood infection. Researchers looked back at hospital data to understand how often sepsis leads to a dangerous blood clotting problem called DIC. The goal was to gather …

This study aimed to better understand how sepsis, a life-threatening infection, can lead to a dangerous blood clotting disorder called DIC. Researchers observed 150 adult sepsis patients in European intensive care units, collecting their standard medical data and blood samples to…