Aids Malignancy Consortium

This completed Phase II trial tested the drug pomalidomide in 26 HIV-positive adults with Kaposi sarcoma, a type of skin cancer common in Sub-Saharan Africa. Pomalidomide works by boosting the immune system and blocking blood vessel growth that feeds tumors. Researchers measured …

This pilot phase 2 trial tested the HIV drug nelfinavir in 36 people with Kaposi sarcoma, a type of cancer. The goal was to see if the drug could shrink or eliminate skin lesions. Researchers looked at how well the drug worked in both HIV-positive and HIV-negative participants, a…

This study tested a drug called sEphB4-HSA in 23 people with Kaposi sarcoma, a type of skin cancer. The drug works by stopping blood vessels from feeding the cancer and may also slow cancer cell growth. The goal was to see how many patients responded to treatment and to check for…

This study looked at whether the HPV vaccine can help prevent high-grade cervical lesions (precancerous growths) in women living with HIV who were already being treated for HPV. About 536 women took part, receiving either the HPV vaccine or a placebo. The goal was to see if the v…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study looked back at 30 people with HIV who received a special cancer treatment called CAR T-cell therapy for certain blood cancers. Researchers collected information from medical records to see what side effects occurred and how the immune system changed over time. The goal…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study followed 10 people with HIV and AIDS-related Kaposi sarcoma in Tanzania to see how their quality of life changed during treatment with vincristine and bleomycin. Participants filled out questionnaires about their physical, emotional, social, and daily functioning over …