Aids Malignancy Consortium

This early-phase trial is testing a CAR-T cell therapy (axicabtagene ciloleucel) in 20 adults with HIV who have aggressive B-cell non-Hodgkin lymphoma that came back or didn't respond to prior treatment. The therapy uses a patient's own immune cells, modified to recognize and att…

This study is testing whether a smartphone app designed for people with HIV can help them quit smoking when they also get a lung cancer screening scan. About 100 participants will use the app and get a low-dose CT scan to check for lung cancer. The goal is to see if this approach…

This phase 2 trial tests whether the drug ixazomib can shrink tumors in people with Kaposi sarcoma, a type of skin cancer. The drug works by blocking enzymes that cancer cells need to grow. About 41 adults with confirmed Kaposi sarcoma will take part to see if the treatment is ef…

This study tests whether adding daratumumab (a targeted antibody) to standard chemotherapy can better treat a rare and aggressive lymphoma called plasmablastic lymphoma. About 15 people with newly diagnosed disease, with or without HIV, will take part. The goal is to see if the c…

This study looks at whether it's possible to safely remove a type of eye cancer called OSSN in people living with HIV in Sub-Saharan Africa. About 84 participants will have surgery and be checked for up to a year. The goal is to see if larger studies on this approach are doable i…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…