XEROSTOMIA

This early-phase study tests whether injecting a person's own bone marrow stem cells into their salivary glands is safe and tolerable for treating dry mouth caused by radiation therapy for head and neck cancer. About 23 participants who finished radiation at least 2 years ago wil…

This study was designed to test a new way of planning radiation therapy for oropharynx cancer. Instead of protecting the whole salivary gland, doctors would use MRI scans to specifically spare the parotid ducts, where stem cells are thought to live. The goal was to reduce severe …

This study tested whether Crest Daily Whitening Serum can reduce dry mouth and bad breath in 27 adults who already have these issues. Participants used the product for one week and reported their symptoms. The goal was to see if a simple whitening gel could provide quick relief f…

This study tests whether a toothpaste with arginine can improve dry mouth (xerostomia) by changing saliva acidity and mouth bacteria. About 70 adults with dry mouth caused by medications will use the toothpaste for 3 months. Researchers will measure saliva pH and oral microbiome …

This study follows 100 head and neck cancer patients before and after radiotherapy to see how it changes their teeth, gums, and saliva over time. Researchers measure gum attachment, pocket depth, and bleeding to understand long-term oral health effects. The goal is to help doctor…