Whitening serum may freshen breath and moisturize mouth
NCT ID NCT06194123
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether Crest Daily Whitening Serum can reduce dry mouth and bad breath in 27 adults who already have these issues. Participants used the product for one week and reported their symptoms. The goal was to see if a simple whitening gel could provide quick relief for dry mouth and perceived halitosis.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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27 people
The number who actually took part.
- Started
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Feb 2024
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * At least 18 years of age. * Can produce an unstimulated salivary flow rate of 0.18mL/min. or less. * Score of 3 or more on question 1 of the VAS dry mouth scale (How severe is your dryness right now?), evaluated in the Pre-Product Use Dry Mouth \& Sensitivity Questionnaire. * Evidence of currently taking a stable dose (3 months or more) of Xerostomia-inducing medication such as, antihypertensives, anti-anxiety agents, psychiatric remedies, antihistamines and etc. • At screening, participants may present the prescription bottle, a picture of the prescriptions bottle or medical records showing the prescription. * Subject not currently using any teeth whitening or desensitizing products that contain potassium nitrate such as Sensodyne, Pronamel etc. * Subject willing to comply with the study regimen and products. * Not consume alcohol for 24 hours prior to their visit. * Not brush their teeth for 1.5 hours prior to their visit. * Not have had anything to eat or drink (including chewing gum or eating candy) for 1.5 hours prior to their visit). Water is acceptable to drink up to 1 hour prior to the study visit. * Not smoke 1.5 hours prior to their visit Exclusion Criteria: i. Subjects who are currently pregnant (self-reported). ii. Unstimulated salivary flow rate of more than 0.18mL/min iii. Subjects that have ever received therapeutic radiation in the head and neck area. iv. Subjects with a diagnosis of conditions that would affect salivary flow such as Sjogren's Syndrome per the investigator's expert opinion. v. Subjects with a condition the investigator believes not suitable for the study, such as autoimmune diseases and radiation therapy to head and neck region that impact salivary flow. vi. Subjects that currently use whitening toothpaste, desensitizing toothpaste, or any other products causing similar results. vii. Subjects currently participating in any other research studies. viii. Subject unable to provide consent (e.g. Cognitively impaired adults). ix. Non-English speaking
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Tufts University School of Dental Medicine
Boston, Massachusetts, 02111, United States
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Other studies related to the condition(s) this trial covers.
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