UVEAL MELANOMA

This early-stage study tests a new radioactive drug (225Ac-MTI-201) in 16 people with advanced uveal melanoma that has spread. The main goal is to find the highest safe dose and understand side effects. Participants receive a single IV dose, and researchers monitor their health c…

This study tests a drug called darovasertib in people with a rare eye cancer (uveal melanoma). The goal is to shrink tumors before standard treatment, possibly avoiding eye removal and reducing radiation damage. About 160 participants will take the drug by mouth to see if it cont…

This study tests a new drug called roginolisib in adults with advanced uveal melanoma, a rare eye cancer that has spread. About 85 participants will receive either roginolisib or standard treatment to see if the drug helps them live longer and improves their quality of life. The …

This early-stage study tests a new drug called IOA-244 in about 210 adults with advanced or metastatic cancers, including lung cancer, melanoma, and lymphoma. The main goal is to see if the drug is safe and tolerable, both alone and with other treatments. Researchers also want to…

This study tests a new way to treat large eye cancers (uveal melanoma). Ten adults with tumors at least 8 mm thick will get chemotherapy injected directly into the eye's blood vessels. A few weeks later, they receive radiation therapy. The goal is to shrink the tumor enough for s…

This study looks at whether eating a high-fiber diet can change the gut bacteria in people with advanced melanoma who are receiving standard immunotherapy. About 50 participants will be randomly assigned to either a high-fiber or a healthy control diet for a period of time. The m…

This study tests a video-based educational program for people who have had uveal melanoma, a rare eye cancer. The goal is to see if the program helps survivors better understand their illness and feel less anxious or depressed. About 108 adults who received treatment at UCLA are …

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers. Researchers look for specific HLA types and tumor antigens to see if patients might qualify for future cell therapy trials. No treatment…

This study follows 500 people with eye melanoma to measure their quality of life before treatment and for five years after. Researchers will track physical and mental health using surveys and interviews. The goal is to understand how different treatments impact daily life, not to…