URINARY BLADDER NEOPLASMS

This study is testing a new treatment for bladder cancer that places a special device (TAR-210) directly into the bladder to release the drug erdafitinib. The goal is to find the best dose and see if it can shrink or eliminate tumors while keeping side effects manageable. About 2…

This early-stage trial tests a drug called sigvotatug vedotin, alone or with other medicines, in people with advanced solid tumors like lung, head and neck, or breast cancer. The goal is to find a safe dose and check for side effects. About 1,000 participants will join this study…

This study tests a new drug called MK-3120 for people with high-risk bladder cancer that hasn't spread into the muscle. After standard surgery to remove the tumor, participants receive MK-3120 directly into the bladder. The main goals are to check safety and find the right dose. …

This early-stage study tests a new drug, LOXO-435, in people with advanced solid tumors, especially bladder cancer, that have a specific change in the FGFR3 gene. The goal is to find the safest dose and see if the drug can shrink tumors, either alone or with other cancer medicine…

This study tests whether adding an experimental drug (V940) to standard BCG immunotherapy can help people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning or spreading. About 308 adults who have not had BCG before will be randomly assig…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder removal surgery is safe and tolerable for people with muscle-invasive bladder cancer. About 150 participants will receive durvalumab alongside either of two chemoth…

This study tests whether two drugs, enfortumab vedotin and pembrolizumab, can control muscle-invasive bladder cancer without needing surgery to remove the bladder. About 390 adults whose cancer hasn't spread outside the bladder will get either the drug combo or standard chemoradi…

This study tests whether adding a new drug called vepugratinib to two standard cancer treatments (enfortumab vedotin and pembrolizumab) helps adults with advanced or spreading bladder cancer that has a specific FGFR3 gene change. About 450 participants will receive either the new…

This early-phase study tests a new MRI technique that uses two contrast dyes to create a detailed image of the bladder wall, helping doctors determine the depth of bladder cancer before surgery. About 42 adults with bladder tumors will undergo this special MRI, and the results wi…

This study compares 3 versus 6 cycles of platinum-based chemotherapy before maintenance avelumab in 320 people with advanced bladder cancer. The main goal is to see which approach leads to better quality of life. Participants receive either 3 or 6 cycles of chemo, then avelumab e…

This study looks at whether starting Blad-Care (a gel that coats the bladder) early during BCG therapy can reduce bladder irritation like pain and urgency in people with non-muscle-invasive bladder cancer. About 56 adults will be randomly assigned to get Blad-Care either early or…

This study follows 400 people who have urologic cancer surgery with lymph node removal to see how often leg swelling (lymphedema) happens. Researchers use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better understand this…