URINARY BLADDER NEOPLASMS

This study is testing whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder removal surgery helps control muscle-invasive bladder cancer better. The research involves 150 patients worldwide who are scheduled for bladder removal surgery…

This study is testing a new medicine called MK-3120 for people with high-risk bladder cancer that is still in the lining of the bladder and hasn't spread to the muscle. The medicine is placed directly into the bladder. The main goals are to see if the treatment is safe and if peo…

This study is testing a new device called TAR-210, which is placed in the bladder to slowly release a cancer drug called erdafitinib. The goal is to treat bladder cancer directly at the site, potentially controlling the disease while reducing side effects that can happen when the…

This study is testing whether adding a new personalized cancer vaccine called V940 to the standard BCG treatment helps people with high-risk bladder cancer stay cancer-free longer. Researchers will compare the combination of V940 plus BCG against BCG treatment alone in about 308 …

This early-stage study is testing a new drug called LOXO-435 for people with advanced solid tumors, including bladder cancer, that have a specific genetic change (FGFR3). The main goals are to find a safe dose, understand side effects, and see if the drug can shrink tumors. The s…

This early-stage trial is testing an experimental drug called sigvotatug vedotin for people with advanced solid tumors that have spread or cannot be removed by surgery. The study will first determine safe doses, then test the drug alone and in combination with other cancer medica…

This study is testing whether adding a new drug called vepugratinib to two existing cancer drugs works better for people with advanced bladder cancer that has spread and has a specific genetic change (FGFR3). About 450 adults who haven't had treatment for their advanced cancer wi…

This study is testing three different types of advanced imaging scans to see which is best at diagnosing a serious form of bladder cancer that has spread into the muscle wall. It will also use these scans to check how well pre-surgery treatments are working for patients. The goal…

This study is testing a new type of MRI scan to see if it can more accurately determine how deep bladder cancer has grown into the bladder wall. Doctors will test the scan on 42 people who are already scheduled for bladder cancer surgery. The goal is to see if this new imaging me…

This study aims to understand how common and severe leg swelling (lymphedema) is after surgery for cancers of the bladder, prostate, testicles, or penis. Researchers will follow 400 patients for up to two years after their surgery, using questionnaires and leg measurements. The g…