UNRESECTABLE HEPATOCELLULAR CARCINOMA

This study is testing a new combination treatment for advanced liver cancer that cannot be removed by surgery. Doctors take a patient's own immune cells, grow and train them in a lab to attack cancer, and then inject them directly into the tumor after radiation. This personalized…

This study is testing whether combining an oral cancer drug called Regorafenib with a targeted radiation treatment (Y-90 radioembolization) can help control advanced liver cancer that cannot be surgically removed. It will involve about 30 adult patients who have not had prior dru…

This study is testing a combination of four treatments for advanced liver cancer that cannot be removed by surgery. The approach includes a targeted radiation therapy delivered directly to the liver tumor, plus three different drugs designed to help the immune system fight the ca…

This study is for people with advanced liver cancer that has spread and cannot be removed by surgery, and whose cancer has continued to grow despite receiving a specific prior immunotherapy combination. It tests whether adding an immunotherapy drug (atezolizumab) to a standard ca…

This study is testing a new, personalized vaccine designed to teach the body's immune system to recognize and attack a patient's specific cancer. It is being given alongside an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that have spread. The …

This pilot study is testing a new strategy for patients with liver cancer that cannot be surgically removed. Researchers will combine immunotherapy (which uses the body's immune system) with highly focused radiation to try to shrink tumors. The goal is to make the cancer small en…

This study is testing the safety of combining two immunotherapy drugs (atezolizumab and bevacizumab) with a precise form of radiation therapy for advanced liver cancer that cannot be surgically removed. The goal is to see if this three-part approach can better control the cancer …

This study is testing a new drug called PF-08634404 to see if it is safe and effective for treating advanced liver cancer that cannot be removed by surgery. It will be given alone or combined with another drug (ipilimumab) to 138 adults who have not had other whole-body treatment…

This study aims to understand which treatments work best for advanced liver cancer patients after they've received initial immunotherapy combinations. Researchers will collect data from 300 adults who have already started their next treatment as part of their regular care. By tra…