UNRESECTABLE HEPATOCELLULAR CARCINOMA

This early-phase trial studies the safety and effectiveness of two immunotherapy drugs (durvalumab and tremelimumab) given after a targeted radiation procedure for patients with advanced liver cancer that cannot be removed by surgery. The treatment aims to help the immune system …

This study tests the safety of adding bumetanide, a common water pill, to a standard procedure that blocks blood flow to liver tumors. About 30 adults with liver cancer that cannot be removed by surgery will receive different doses. The goal is to see if the combination can slow …

This study is checking how well a drug combination (atezolizumab plus bevacizumab) works when added to local treatments like chemoembolization or radiation for people with advanced liver cancer that can't be removed by surgery. About 1,136 patients from hospitals in China and the…

This study tests whether adding the immunotherapy drug atezolizumab to standard targeted therapy (lenvatinib or sorafenib) helps people with advanced liver cancer live longer. It includes 557 adults whose cancer worsened after initial treatment with atezolizumab and bevacizumab. …

This study is testing a treatment called selective internal radiation therapy (SIRT) for people with liver cancer that cannot be surgically removed. Tiny radioactive beads are injected into the liver to deliver radiation directly to tumors. The goal is to shrink the cancer and co…

This study compares two radiation therapies for people with liver cancer that cannot be removed by surgery or has come back. One uses standard X-rays (photons), the other uses proton beams that stop after the tumor, possibly causing less harm to healthy tissue. The goal is to see…

This study tests a new drug called pevonedistat, given alone or with standard chemotherapy, in 40 adults with advanced bile duct cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors or stop them from growing. Participants must have …

This study tests whether giving a personalized dose of radiation directly to liver tumors can improve treatment results for people with advanced liver cancer that cannot be removed by surgery. About 42 participants will receive a customized radiation plan based on their individua…

This study watches adults with a type of liver cancer that can't be removed by surgery. They have already received a first-line treatment and are now starting a second treatment. Researchers will collect data from medical records to see how long patients live and how well the sec…

This study looked back at medical records from 800 adults with unresectable hepatocellular carcinoma (a type of liver cancer that cannot be removed by surgery) who were treated with lenvatinib-based therapy at six hospitals. The goal was to see how long patients lived and how wel…