New drug combo shows promise against tough bile duct cancer

NCT ID NCT04175912

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether adding pevonedistat to standard chemotherapy (carboplatin and paclitaxel) can shrink tumors in people with advanced bile duct cancer that has spread or cannot be removed. About 40 adults whose cancer progressed after gemcitabine-based chemo will receive the combination. The main goal is to see how many patients have their tumors shrink significantly.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Pevonedistat (a drug that blocks an enzyme needed for cancer cell growth) combined with carboplatin and paclitaxel (standard chemotherapy drugs)
What this could lead to: If this works, it could offer a new treatment option for people with advanced bile duct cancer that has stopped responding to standard chemotherapy.
What could go wrong: This is a small, early-phase trial with only 40 participants. The combination may not shrink tumors better than existing treatments, and side effects from adding pevonedistat to chemotherapy are not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

40 people

The number who actually took part.

Started

Mar 2020

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must be \>= 18 years of age * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Patient must have a life expectancy \>= 12 weeks * Patient must have histologically confirmed intrahepatic cholangiocarcinoma or biphasic hepatocellular carcinoma and cholangiocarcinoma that is metastatic or unresectable and who have progressed on or been intolerant of one prior line of systemic gemcitabine containing chemotherapy regimen. * NOTE: Prior immunotherapy or targeted therapies are allowed and will not be considered a line of therapy unless administered with cytotoxic chemotherapy * Patient must have measurable disease. For patients who have received localized therapy (embolization, chemoembolization, radiofrequency ablation or radiation) are eligible if measurable disease is not within the treatment field or the treated disease has clearly progressed since last localized therapy * Leukocytes \>= 3,000/mcL (obtained within 14 days prior to randomization) * Absolute neutrophil count \>= 1,500/mcL (obtained within 14 days prior to randomization) * Platelets \>= 100,000/mcL (obtained within 14 days prior to randomization) * Total bilirubin =\< institutional upper limit of normal (ULN) except in patients with Gilbert's syndrome. Patients with Gilbert's syndrome may enroll if direct bilirubin =\< 1.5 x ULN of the direct bilirubin (obtained within 14 days prior to randomization) * Hemoglobin \>= 9 g/dL (obtained within 14 days prior to randomization) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (obtained within 14 days prior to randomization) * Creatinine =\< institutional ULN, OR glomerular filtration rate (GFR) \>= 40 mL/min/1.73 m\^2 (obtained within 14 days prior to randomization) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. Known HIV positive patients who meet the following criteria will be considered eligible: * CD4 count \>= 350 cells/mm\^3 * Undetectable viral load * Maintained on modern therapeutic regimens utilizing non-CYP interactive agents (i.e. excluding ritonavir) * No history of acquired immunodeficiency syndrome (AIDS)-defining opportunistic infections * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patients who received prior platinum or taxane chemotherapy are eligible * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better. In addition, patients with any of the known cardiopulmonary disease, defined as follows, would be ineligible for this trial: * Unstable angina * Congestive heart failure (New York Heart Association \[NYHA\] class III or IV;); * Myocardial infarction within 6 months prior to randomization (patients who had ischemic heart disease such as acute coronary syndrome \[ACS\], myocardial infarction, and/or revascularization greater than 6 months before randomization and who are without cardiac symptoms may enroll) * Symptomatic cardiomyopathy * Clinically symptomatic pulmonary hypertension requiring pharmacologic therapy * Clinically significant arrhythmia, defined as: * History of polymorphic ventricular fibrillation or torsade de pointes, * Permanent atrial fibrillation, defined as continuous atrial fibrillation for \>= 6 months, * Persistent atrial fibrillation, defined as sustained atrial fibrillation lasting \> 7 days and/or requiring cardioversion in the 4 weeks before randomization, * Grade 3 atrial fibrillation defined as symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation * Patients with paroxysmal atrial fibrillation or grade \< 3 atrial fibrillation for period of at least 6 months are permitted to enroll provided that their rate is controlled on a stable regimen * Patients must have the ability to understand and the willingness to sign a written informed consent document * Participants with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible Exclusion Criteria: * Patients must not have had major surgery within 14 days before randomization. Patients with surgery planned during study period are ineligible * Women must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. Patients must also not expect to conceive or father children from the time of registration, while on study treatment, and until at least 4 months after the last dose of study treatment. All females of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Women of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and continue for at least 4 months after the last dose of protocol treatment * Male patients must not donate sperm during the course of this study or within 4 months after receiving their last dose of protocol treatment * Female patients must not donate eggs (ova) during the course of this study or within 4 months after receiving their last dose of protocol treatment * Patient must not have a prolonged rate corrected QT (QTc) interval \>= 480 msec calculated according to institutional guideline * Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e. have residual toxicities \> grade 1) are ineligible with the exception of alopecia * Patients with persistent \>= grade 2 diarrhea lasting more than 3 days within 14 weeks of randomization are ineligible * Patients with known central nervous system (CNS) involvement are ineligible * Patients must not be receiving any other investigational agents * Patients must not have received chemotherapy or radiotherapy within 2 weeks prior to randomization. Prior treatment with radiation therapy involving \>= 25% of hematopoietically active bone marrow will be ineligible * Patients must not have received immunotherapy within 8 weeks prior to randomization * Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to pevonedistat, carboplatin, or paclitaxel * Patient must not be receiving any treatment with clinically significant metabolic enzyme inducers within 14 days before the first dose of the study drug as below. Clinically significant metabolic enzyme inducers are not permitted during the study. Patients must not be receiving any medications or substances that are strong inducers of CYP3A4/5 (i.e. phenytoin, rifampin, St. Johns wort) or inhibitors of breast cancer resistance protein (BCRP) (i.e. cyclosporine). Because the lists of these agents are constantly changing, it is important to regularly consult a frequently-updated medical reference. As part of enrollment/informed consent procedures, the patient will be counseled on the risk of interactions with other agents, and what to do if a new medication need to be prescribed or if the patient is considering a new over-the-counter medicine or herbal product. Inhibitors of CYP3A4/5 are allowed * Patients must not have uncontrolled intercurrent illness * Patients must not have uncontrolled coagulopathy or bleeding disorder * Patients must not have active, uncontrolled infection or severe infectious disease such as severe pneumonia, meningitis, or septicemia * Patients with known moderate chronic obstructive pulmonary disease, interstitial lung disease, and pulmonary fibrosis are ineligible * Patients must not have psychiatric illness/social situations that would limit compliance with study requirements * Participants must not have had prior pevonedistat treatment

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Sign up to get updates when this study changes or when new studies for Biphasic hepatocellular carcinoma and cholangiocarcinoma are added.

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma combined hepatocellular carcinoma and cholangiocarcinoma hepatocellular carcinoma intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic cholangiocarcinoma Metastatic hepatocellular carcinoma Stage III hepatocellular carcinoma ajcc V8 Stage III intrahepatic cholangiocarcinoma ajcc V8 Stage IIIA hepatocellular carcinoma ajcc V8 Stage IIIA intrahepatic cholangiocarcinoma ajcc V8 Stage IIIB hepatocellular carcinoma ajcc V8 Stage IIIB intrahepatic cholangiocarcinoma ajcc V8 Stage IV hepatocellular carcinoma ajcc V8 Stage IV intrahepatic cholangiocarcinoma ajcc V8 Stage IVA hepatocellular carcinoma ajcc V8 Stage IVB hepatocellular carcinoma ajcc V8 Unresectable cholangiocarcinoma Unresectable hepatocellular carcinoma Unresectable intrahepatic cholangiocarcinoma

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States
AdventHealth Littleton

Littleton, Colorado, 80122, United States
AdventHealth Parker

Parker, Colorado, 80138, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States
Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Ann M Wierman MD LTD

Las Vegas, Nevada, 89128, United States
Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Ballad Health Cancer Care - Bristol

Bristol, Virginia, 24201, United States
Ballad Health Cancer Care - Kingsport

Kingsport, Tennessee, 37660, United States
Ballad Health Cancer Care - Norton

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Bay Area Hospital

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Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States
Benefis Sletten Cancer Institute

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Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Bozeman Health Deaconess Hospital

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Bristol Regional Medical Center

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Broadlawns Medical Center

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Bronson Battle Creek

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Bronson Methodist Hospital

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CHI Health Good Samaritan

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CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
California Pacific Medical Center-Pacific Campus

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Cambridge Medical Center

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Cancer Care and Hematology-Fort Collins

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Cancer Center at Saint Joseph's

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Cancer Center of Western Wisconsin

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Cancer Centers of Southwest Oklahoma Research

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Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States
Cancer and Blood Specialists-Henderson

Henderson, Nevada, 89052, United States
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Clackamas Radiation Oncology Center

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Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906, United States
Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
CommonSpirit Cancer Center Mercy

Durango, Colorado, 81301, United States
CommonSpirit Saint Anthony Hospital Cancer Center

Lakewood, Colorado, 80228, United States
CommonSpirit Saint Joseph Hospital - Bardstown

Bardstown, Kentucky, 40004, United States
CommonSpirit Saint Joseph Hospital London

London, Kentucky, 40741, United States
CommonSpirit Saint Joseph Medical Center - East Lexington

Lexington, Kentucky, 40509, United States
Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States
Community Hospital of Anaconda

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Grand Rapids, Michigan, 49503, United States
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Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
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Centerville, Ohio, 45459, United States
Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States
Desert West Surgery

Las Vegas, Nevada, 89102, United States
East Carolina University

Greenville, North Carolina, 27834, United States
Eden Hospital Medical Center

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Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
First Dayton Cancer Care

Kettering, Ohio, 45420, United States
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Indianapolis, Indiana, 46237, United States
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Mooresville, Indiana, 46158, United States
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West Bend, Wisconsin, 53095, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
HaysMed

Hays, Kansas, 67601, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, 89149, United States
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Las Vegas, Nevada, 89109, United States
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Las Vegas, Nevada, 89113, United States
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Las Vegas, Nevada, 89128, United States
Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093, United States
Henry Ford River District Hospital

East China Township, Michigan, 48054, United States
Henry Ford Rochester Hospital

Rochester Hills, Michigan, 48309, United States
Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States
Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044, United States
Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States
Holy Name Hospital

Teaneck, New Jersey, 07666, United States
Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States
Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, 89048, United States
Hope Cancer Center

Pontiac, Michigan, 48341, United States
Hope Cancer Clinic

Livonia, Michigan, 48154, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Island Urology

Honolulu, Hawaii, 96813, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kingman Regional Medical Center

Kingman, Arizona, 86401, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Las Vegas Cancer Center-Henderson

Henderson, Nevada, 89052, United States
Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, 89148-2405, United States
Las Vegas Prostate Cancer Center

Las Vegas, Nevada, 89113, United States
Las Vegas Urology - Cathedral Rock

Las Vegas, Nevada, 89128, United States
Las Vegas Urology - Green Valley

Henderson, Nevada, 89074, United States
Las Vegas Urology - Pebble

Henderson, Nevada, 89074, United States
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Las Vegas, Nevada, 89074, United States
Las Vegas Urology - Smoke Ranch

Las Vegas, Nevada, 89128, United States
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Las Vegas, Nevada, 89113, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
McFarland Clinic - Boone

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States
McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858, United States
McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
McLaren-Port Huron

Port Huron, Michigan, 48060, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Memorial Medical Center

Modesto, California, 95355, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States
Mercy Medical Center

Springfield, Massachusetts, 01104, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Michigan Healthcare Professionals Pontiac

Pontiac, Michigan, 48341, United States
Mid-Michigan Physicians-Lansing

Lansing, Michigan, 48912, United States
Midlands Community Hospital

Papillion, Nebraska, 68046, United States
Mills Health Center

San Mateo, California, 94401, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States
Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Oncology Las Vegas - Henderson

Henderson, Nevada, 89074, United States
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Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States
OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183, United States
OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States
Orion Cancer Care

Findlay, Ohio, 45840, United States
Overlake Medical Center

Bellevue, Washington, 98004, United States
PCR Oncology

Arroyo Grande, California, 93420, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Palo Alto Medical Foundation Health Care

Palo Alto, California, 94301, United States
Palo Alto Medical Foundation-Camino Division

Mountain View, California, 94040, United States
Palo Alto Medical Foundation-Fremont

Fremont, California, 94538, United States
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Mountain View, California, 94040, United States
Palo Alto Medical Foundation-Santa Cruz

Santa Cruz, California, 95065, United States
Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, 94086, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Memorial Hospital

Dallas, Texas, 75235, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Radiation Oncology Associates

Reno, Nevada, 89509, United States
Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States
Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Reid Health

Richmond, Indiana, 47374, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States
Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Medical Center Hematology and Oncology - Silverdale

Silverdale, Washington, 98383, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States
Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States
Saint Mary's Regional Medical Center

Reno, Nevada, 89503, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Singh and Arora Hematology Oncology PC

Flint, Michigan, 48532, United States
South Pointe Hospital

Warrensville Heights, Ohio, 44122, United States
Sovah Health Martinsville

Martinsville, Virginia, 24112, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144, United States
Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109, United States
Sutter Auburn Faith Hospital

Auburn, California, 95602, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Davis Hospital

Davis, California, 95616, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Pacific Medical Foundation

Santa Rosa, California, 95403, United States
Sutter Roseville Medical Center

Roseville, California, 95661, United States
Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States
TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States
TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge

Fort Dodge, Iowa, 50501, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104, United States
Union Hospital

Terre Haute, Indiana, 47804, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Cancer Center

Las Vegas, Nevada, 89169, United States
University Health Truman Medical Center

Kansas City, Missouri, 64108, United States
University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Cancer Center-West

Kansas City, Kansas, 66112, United States
University of Kansas Clinical Research Center

Fairway, Kansas, 66205, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of North Carolina-Hillsborough Campus

Hillsborough, North Carolina, 27278, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Urology Specialists of Nevada - Central

Las Vegas, Nevada, 89106, United States
Urology Specialists of Nevada - Green Valley

Henderson, Nevada, 89074, United States
Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, 89113, United States
Valley Medical Center

Renton, Washington, 98055, United States
Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States
Vanderbilt-Ingram Cancer Center at Franklin

Franklin, Tennessee, 37067, United States
Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

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