ULCERATIVE COLITIS (UC)

This pilot study tests whether the antibiotic vancomycin can safely treat active ulcerative colitis in adults who also have primary sclerosing cholangitis, a liver condition. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an optional 4-week extension. T…

This study tests a new drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely controls symptoms like bleeding and diarrhea. Participants must have tried other treatments without success.

This study compares a new strategy using stool tests to guide treatment for ulcerative colitis against standard care. About 240 adults with inactive disease will be randomly assigned to one of two groups. The goal is to see if the stool-test approach can better prevent relapses, …

This early-phase study tests a new drug, cizutamig, in 15 adults with moderate to severe ulcerative colitis who have not responded to other treatments. The main goal is to check if the drug is safe and tolerable. Researchers will monitor side effects and how the body reacts to th…

This study tests whether a daily synbiotic formula (SGR11) can improve symptoms and quality of life in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants take the formula for 8 weeks and complete questionnaires and stool tests t…

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This study will give 80 people with Crohn's disease or ulcerative colitis a smartwatch and a loyalty card to track their daily activity and food purchases. Researchers want to see if this data can help detect when the disease flares up. The goal is to find new ways to monitor IBD…

This study will give 150 adults with Crohn's disease or ulcerative colitis a daily 2000 IU vitamin D supplement for 12 months. Researchers want to see if patients stick with the supplement and whether it improves their quality of life. Participants will complete surveys, blood te…

This pilot study will test whether a modified ultrasound technique can accurately measure disease activity in people with moderate-to-severe ulcerative colitis. Researchers will compare ultrasound results with standard colonoscopy findings in 25 patients starting a new treatment.…

This study tests a new imaging method to see if two common IBD drugs (adalimumab and risankizumab) actually reach the inflamed gut tissue. About 30 adults with ulcerative colitis or Crohn's disease will receive a tiny dose of fluorescent versions of these drugs before a routine c…

This study looks at why fecal transplants succeed or fail in treating recurrent C. diff, ulcerative colitis, and metabolic syndrome. Researchers will track gut bacteria, viruses, fungi, immune cells, and metabolites in 90 adults over time. The goal is to find patterns that predic…