Ulcerative colitis (disorder)

This study is testing whether guselkumab, a biologic drug, can help people with moderate-to-severe ulcerative colitis achieve remission. Participants receive IV infusions followed by maintenance injections. The trial tracks clinical, endoscopic, and histological healing over 48 w…

This trial tests whether a 12-week dietary intervention can improve gut health, reduce inflammation, and enhance quality of life in adults with ulcerative colitis who are in remission. Participants are randomly assigned to a Mediterranean diet, a Mediterranean diet combined with …

This study is testing a new oral drug called etrasimod in 30 elderly patients with active ulcerative colitis. Researchers will track how many patients achieve remission after 4 weeks and look for improvements in the gut lining after a year. The goal is to see if the drug is safe …

This study tests whether a special medical food called LH VIOLA, taken as a partial replacement for regular meals, can help people with Crohn's disease or ulcerative colitis who are at risk of malnutrition maintain or regain weight and muscle strength. About 146 participants will…

This early-stage trial tests BDHK-2009, an experimental tablet for inflammatory bowel diseases like ulcerative colitis and Crohn's disease. The study involves 68 healthy adults aged 18 to 55 to see if the drug is safe and how the body handles it. Participants receive either a sin…

This study tests a dietary supplement called ButyMixx in 40 adults with ulcerative colitis who are in remission. ButyMixx contains sodium butyrate and a beneficial yeast to support gut health. Participants take two sachets daily for 8 weeks, and researchers check for symptom chan…

This pilot study is testing whether drinking 8 ounces of pomegranate juice daily for 8 weeks can reduce gut inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. Researchers will also look at how the juice affects gut bacteria. The study inv…

Researchers collect small tissue samples from the inflamed and non-inflamed intestines of people with Crohn's disease or ulcerative colitis, as well as from people without inflammatory bowel disease. They grow these cells into tiny three-dimensional structures called organoids th…