Transformed chronic lymphocytic leukemia to diffuse large B-cell lymphoma
Clinical trials for Transformed chronic lymphocytic leukemia to diffuse large B-cell lymphoma explained in plain language.
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Experimental combo targets Hard-to-Treat blood cancer
Disease control Recruiting nowThis early-phase trial is testing whether combining two drugs—zanubrutinib and odronextamab—is safe for people with Richter's transformation, a rare and aggressive form of blood cancer that arises from chronic lymphocytic leukemia. The study will enroll 23 adults and monitor for …
Matched conditions: TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA TO DIFFUSE LARGE B-CELL LYMPHOMA
Phase 1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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New combo therapy takes on tough lymphoma
Disease control Recruiting nowThis study tests a combination of two treatments—zanubrutinib (a targeted drug) and lisocabtagene maraleucel (a CAR T-cell therapy)—for people with Richter's syndrome, an aggressive lymphoma that can develop from chronic lymphocytic leukemia. The goal is to see if this combo can …
Matched conditions: TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA TO DIFFUSE LARGE B-CELL LYMPHOMA
Phase 2 • Sponsor: Aseel Alsouqi • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC