TOTAL NEOADJUVANT TREATMENT
Clinical trials for TOTAL NEOADJUVANT TREATMENT explained in plain language.
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New combo therapy aims to shrink rectal tumors before surgery
Disease control Recruiting nowThis study tests whether adding an immunotherapy drug (PD-1 inhibitor) to a standard treatment plan (short-course radiation, chemotherapy, and a targeted therapy) can improve outcomes for people with locally advanced rectal cancer. About 104 adults with a specific type of rectal …
Matched conditions: TOTAL NEOADJUVANT TREATMENT
Phase: PHASE2 • Sponsor: Ruijin Hospital • Aim: Disease control
Last updated May 26, 2026 05:28 UTC
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Breakthrough trial may let rectal cancer patients keep their rectum
Disease control Recruiting nowThis study tests whether a treatment plan called total neoadjuvant therapy (TNT) can help about half of rectal cancer patients avoid surgery and keep their rectum. Participants receive chemotherapy and radiation before deciding if they need surgery. Those who respond very well ar…
Matched conditions: TOTAL NEOADJUVANT TREATMENT
Phase: PHASE2, PHASE3 • Sponsor: National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos • Aim: Disease control
Last updated May 26, 2026 04:38 UTC
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New combo therapy before surgery shows promise for esophageal cancer
Disease control Recruiting nowThis study tests a new approach for people with a type of esophageal cancer that has spread locally but not to distant organs. Participants receive a combination of immunotherapy and chemotherapy, followed by chemoradiation, and then surgery. The goal is to see if this sequence c…
Matched conditions: TOTAL NEOADJUVANT TREATMENT
Phase: PHASE2 • Sponsor: National Taiwan University Hospital • Aim: Disease control
Last updated May 22, 2026 14:05 UTC