Stiff person syndrome
Clinical trials for Stiff person syndrome explained in plain language.
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Can CRISPR-Edited cells stop autoimmune attacks on the brain?
Cure Not yet recruitingThis trial tests a therapy called CTX112 in adults with severe neurologic autoimmune diseases, including progressive multiple sclerosis, neuromyelitis optica, and stiff-person syndrome. CTX112 uses donor T cells edited with CRISPR to target and deplete B cells, which are thought …
Matched conditions: STIFF PERSON SYNDROME
Phase 1/2 • Sponsor: CRISPR Therapeutics • Aim: Cure
Last updated Sep 11, 2026 00:00 UTC
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Experimental CAR-T therapy targets Hard-to-Treat brain autoimmune diseases
Disease control Not yet recruitingThis early-stage trial is testing a new treatment called C-CAR168, which uses a patient's own immune cells modified to attack harmful cells in the body. It is for 15 adults with multiple sclerosis, neuromyelitis optica, autoimmune encephalitis, or stiff person syndrome that have …
Matched conditions: STIFF PERSON SYNDROME
Phase 1 • Sponsor: Huashan Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New hope for stiff person syndrome: drug trial aims to ease muscle stiffness and improve walking
Symptom relief Not yet recruitingThis study tests a medicine called IGIV 10% (a type of antibody treatment) against a placebo in 38 adults aged 18-70 with Stiff Person Syndrome, a rare condition causing muscle stiffness and spasms. The main goal is to see if the drug helps people walk faster (measured by a 25-fo…
Matched conditions: STIFF PERSON SYNDROME
Phase 3 • Sponsor: Kedrion S.p.A. • Aim: Symptom relief
Last updated Sep 16, 2026 00:00 UTC