STARGARDT DISEASE

This study tests whether metformin, a pill used for diabetes, can safely slow vision loss in people with ABCA4 retinopathy (including Stargardt disease). About 56 participants aged 12 and older will take metformin daily for 24 months. Researchers will measure changes in the retin…

This study tests an investigational drug called gildeuretinol acetate (ALK 001) in 230 people aged 8 to 45 with Stargardt disease, an inherited condition that causes progressive vision loss. The goal is to see if the drug can slow the growth of damage in the retina and help prese…

This early-stage study tests the safety of a single injection of RTx-021 into the eye for people with Stargardt disease, a genetic condition that causes vision loss. Up to 18 participants will receive one of three doses and be followed for 5 years. The goal is to see if the treat…

This early study tests a single injection of ACDN-01 into the eye for people with Stargardt disease or related vision loss caused by ABCA4 gene mutations. The main goal is to check safety and find the best dose. Up to 15 adults with advanced vision loss will take part. The therap…

This study tests a device called PRIMA, which is implanted in the eye to help restore central vision in people with inherited retinal diseases like Stargardt disease and retinitis pigmentosa. Five adults with severe vision loss will receive the implant and be monitored for improv…

This study tests a one-time gene therapy injection (AAVB-039) into the eye for people with Stargardt disease, a genetic condition that causes progressive vision loss. The trial involves 75 participants and will first check safety, then measure if the treatment can slow damage to …

This early-phase study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration. Researchers believe it may reduce harmful activity in the retina. The study involves 15 adults with inherited retinal disease …

This study is a prescreening step to find people with a specific genetic eye condition called ABCA4-related retinopathy, which includes Stargardt disease and cone-rod dystrophy. About 50 participants will undergo genetic testing and eye exams to see if they qualify for future tri…

This study follows 75 people with Stargardt disease type 1, a genetic eye condition that causes vision loss. Researchers will use eye scans and vision tests over time to measure how the disease progresses. The goal is to better understand the disease's natural course, which can h…

This early-stage study tests the safety and how the body processes an experimental oral drug called DC6001 in 76 healthy adults aged 18-55. The drug is being developed for Stargardt disease, a rare inherited eye condition that causes vision loss. Participants will receive either …

This registry collects health information from people with inherited retinal diseases to help researchers better understand these conditions. Participants create an online profile and can update it over time. The goal is to speed up research and connect people with clinical trial…

This study is for people with severe vision loss from diseases like retinitis pigmentosa or Stargardt disease. The goal is to find out which vision tests work best for people with very low vision, so future treatments can be measured more accurately. About 25 participants will tr…

This study follows children (over 6) and adults with Stargardt disease or similar inherited eye conditions to see how their vision changes over 2 years. Participants get standard eye tests every 6 months, but no new treatment is given. The goal is to better understand how these d…