STAGE IVA PROSTATE CANCER AJCC V8
Clinical trials for STAGE IVA PROSTATE CANCER AJCC V8 explained in plain language.
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New cocktail of cancer drugs tested in advanced tumors
Disease control OngoingThis study tests the safety and effectiveness of combining the immunotherapy drug avelumab with other treatments (utomilumab, ivuxolimab, or radiation) in 173 people with advanced cancers that have not responded to standard therapies. The goal is to find tolerable doses and see i…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 23, 2026 11:57 UTC
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Gene test guides prostate cancer treatment: less or more hormone therapy?
Disease control OngoingThis study tests whether personalizing hormone therapy based on a patient's genetic risk score can improve prostate cancer treatment. For patients with a low genetic risk, a shorter course of hormone therapy (12 months instead of 24) with radiation is tested to see if it works ju…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 22, 2026 12:05 UTC
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Supercharged immune cells take on Hard-to-Treat prostate cancer
Disease control OngoingThis early-phase trial tests a new type of immunotherapy called PSCA-CAR T cells in 14 men with metastatic castration-resistant prostate cancer that has spread and stopped responding to standard hormone therapy. The treatment involves taking a patient's own immune cells, engineer…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 22, 2026 11:55 UTC
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Double-Drug attack shows promise for Tough-to-Treat prostate cancer
Disease control OngoingThis study tests whether adding rucaparib to standard enzalutamide helps men with metastatic prostate cancer that has stopped responding to hormone therapy. About 61 men will receive either the combination or enzalutamide alone. The goal is to see if the combo slows cancer growth…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 17, 2026 12:09 UTC
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New combo therapy targets Hard-to-Treat cancers
Disease control OngoingThis early-stage trial tests a new drug (DS3201) combined with an immunotherapy (ipilimumab) in adults with advanced prostate, bladder, or kidney cancer that has spread. The goal is to find the safest dose and see if the combination can help control the disease. About 65 particip…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 16, 2026 12:49 UTC
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Shorter radiation blasts may be safer and just as effective for prostate cancer
Disease control OngoingThis study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer course for men with prostate cancer who have had their prostate removed. About 186 men will be randomly assigned to one of the two radiation plans. The main …
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 15, 2026 18:55 UTC
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Prostate cancer patients may get a break from hormone shots
Disease control OngoingThis study looks at whether men whose metastatic prostate cancer has responded very well to hormone therapy can safely pause treatment. About 79 men will stop their medications under doctor guidance to see if their testosterone levels recover and they remain cancer-free for at le…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 10, 2026 13:27 UTC
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New drug cocktail aims to stall advanced prostate cancer in Early-Stage patients
Disease control OngoingThis study tests a combination of three drugs (abiraterone, prednisone, and apalutamide) in 60 men whose prostate cancer has spread but who have not yet received hormone therapy. The goal is to see how long patients can stay on treatment and to measure cancer progression and side…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 01, 2026 18:06 UTC
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Fasting during radiation may ease treatment side effects
Symptom relief OngoingThis study compares time-restricted eating (intermittent fasting) with standard nutritional counseling in cancer patients receiving radiation or chemoradiation for prostate, cervical, or rectal cancers. The goal is to see if fasting reduces treatment side effects and improves how…
Matched conditions: STAGE IVA PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Jun 22, 2026 12:08 UTC