STAGE IV PANCREATIC CANCER AJCC V8

This study tests whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) helps shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA or PALB2 gene mutations. About 83 participants will receive either the chemo a…

This study tests whether adding cisplatin to the standard two-drug chemo (nab-paclitaxel and gemcitabine) works better for people with metastatic pancreatic cancer who have BRCA1/2 or PALB2 gene mutations. The trial aims to see if the three-drug combo shrinks tumors more and help…

This phase II trial is testing whether combining two targeted drugs, palbociclib and binimetinib, can help people with cancers that have RAS mutations. The study includes patients with pancreatic cancer, ovarian cancer, and other solid tumors. Researchers want to see if the drug …

This early-phase trial tests a combination of two drugs, calaspargase pegol-mknl and cobimetinib, in 15 people with advanced or metastatic pancreatic cancer. The goal is to find the safest dose and see if the combo can shrink tumors by cutting off their nutrient supply. It is a s…

This study tests whether a combination of two drugs, lenvatinib and pembrolizumab, can help keep advanced pancreatic cancer from getting worse. The trial involves 28 adults whose cancer cannot be removed by surgery and who have already responded to initial treatment. The goal is …

This phase II trial is testing two different chemotherapy combinations in 176 older patients whose pancreatic cancer has spread. One group gets gemcitabine plus nab-paclitaxel, the other gets fluorouracil, leucovorin, and liposomal irinotecan. The goal is to see which treatment h…

This early-phase trial tests a new drug called M6620 (berzosertib) combined with the chemotherapy irinotecan in people with advanced solid tumors that have spread or can't be removed. The goal is to find the safest dose and see if the combination can slow tumor growth. About 66 p…

This early-phase study tests a new drug (BAY 1895344) combined with standard chemotherapy (irinotecan or topotecan) in people with advanced solid tumors, including small cell lung cancer, neuroendocrine cancer, and pancreatic cancer. The goal is to find the safest dose and check …

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

This early-stage trial tests a new drug called CA-4948 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in people with pancreatic cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink …

This study tests a new method called sonoporation, which uses ultrasound and tiny gas bubbles to help chemotherapy drugs get into cancer cells more effectively. The trial includes 120 adults with advanced or hard-to-remove pancreatic cancer who are already receiving standard chem…

This phase 2 trial tests whether adding pembrolizumab (an immunotherapy) to olaparib (a targeted therapy) works better than olaparib alone for controlling metastatic pancreatic cancer in people with inherited BRCA1 or BRCA2 mutations. About 88 participants will receive either the…

This early-phase study tests a new drug combination for people with advanced pancreatic cancer that has a specific marker (mesothelin). The treatment pairs a targeted chemotherapy with immunotherapy drugs and standard chemo to see if it's safe and what dose works best. About 74 a…

This early-stage trial aimed to test the safety of a new treatment called STIL101 for people with advanced pancreatic, colorectal, kidney, cervical cancer, or melanoma that has spread or cannot be removed. STIL101 is made from a patient's own immune cells taken from their tumor, …

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…

This study tests whether a supervised, at-home resistance training program using a tablet is safe and helpful for people with advanced pancreatic cancer or those recovering from surgery. About 25 participants will do guided exercises during chemotherapy or after surgery. The goal…